As the building blocks of biological membranes, lipids have a very complex set of behaviors that, when defective, can be a major distributor of diseases, including cancer. As the only book to date devoted entirely to lipids in membranes, Membrane Asymmetry and Transmembrane Motion of Lipids enlists leading research groups to present up-to-date quantitative data on the formation, stability and biological consequences of the asymmetrical organization of lipids in cell membranes. With an impressive amount of data, this book explores exciting new discoveries that show promising potential for future study-- The multi-authored book contains modern information on all major aspects related to the formation, stability and biological consequences of the asymmetrical organization of lipids in cell membranes. It introduces the phenomenon of membrane asymmetry, describes transmembrane distribution of lipids in biological membranes, represents methods for the measurement of the transmembrane lipid motion, emphasizes the role of flippases, discusses biological functions associated with lipid asymmetry and outlines correlations between lipid asymmetry and human diseases such as thrombosis, cancer, and apoptosis-- The first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONSTransmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes.Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems.The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.
Introduction List of Contributors.
Part I: ASSESSING TRANSMEMBRANE MOVEMENT AND ASYMMETRY OF LIPIDS.
1. Methods for the Determination of Lipid Transmembrane Distribution and
Movement in Biological Membranes (Philippe F. Devaux and Andreas Herrmann).
2. Detection and Measurement of Unlabeled Lipid Transmembrane Movement(Iván
López-Montero, Marisela Vélez and Philippe F. Devaux).
Part II: LIPID ASYMMETRY IN CELL MEMBRANES.
3. New Insights in Membrane Lipid Asymmetry in Animal and Plant Cells (Alain
Zachowski).
4. Sphingolipid Asymmetry and Transmembrane Translocation in Mammalian Cells
(Gerrit van Meer, Sylvia Neumann, and Per Haberkant).
5. Transbilayer Movement and Distribution of Cholesterol (Peter Müller, Anna
Pia Plazzo, and Andreas Herrmann).
Part III. ENERGY-INDEPENDENT PROTEIN-MEDIATED TRANSMEMBRANE MOVEMENT OF
LIPIDS.
6. Phospholipid Flip-Flop in Biogenic Membranes (Anant K. Menon and Andreas
Herrmann).
7. Phospholipid Scramblase: When Phospholipid Asymmetry Goes Away (Edouard
M. Bevers and Patrick L. Williamson).
Part IV: ENERGY-DEPENDENT LIPID TRANSPORT ACROSS MEMBRANES.
8. Flip or Flop: Mechanism and (Patho)Physiology of P4-ATPase-Catalyzed
Lipid Transport (Patricia M. Verhulst, Joost C.M. Holthuis, and Thomas G.
Pomorski).
9. Coupling Drs2p to Phospholipid Translocation, Membrane Asymmetry, and
Vesicle Budding (Xiaoming Zhou, Paramasivam Natarajan, Baby-Periyanayaki
Muthusamy, Todd R. Graham, and Ke Liu).
10. Substrate Specifi city of the Aminophospholipid Flippase (Shelley M.
Cook and David L. Daleke).
11. The Flippase Delusion? (Naomi L. Pollock, Petra H.M. Niesten, and
Richard Callaghan).
Part V: RELEVANCE OF LIPID TRANSMEMBRANE DISTRIBUTION FOR MEMBRANE
PROPERTIES AND PROCESSES
12. Membrane Lipid Asymmetry and Permeability to Drugs: A Matter of Size
(Adam Blanchard and Cyril Rauch).
13. Endocytosis and Lipid Asymmetry (Nina Ohlwein, Andreas Herrmann, and
Philippe F. Devaux).
Part VI: APOPTOSIS AND DISEASES: CONSEQUENCES OF DISRUPTION TO LIPID
TRANSMEMBRANE ASYMMETRY
14. Membrane Lipid Asymmetry in Aging and Apoptosis (Krishnakumar
Balasubramanian and Alan J. Schroit).
15. Phosphatidylserine Exposure in Hemoglobinopathies (Frans A. Kuypers and
Eric Soupene).
16. Scott Syndrome: More Than a Hereditary Defect of Plasma Membrane
Remodeling (Florence Toti and Jean-Marie Freyssinet).
17. ABCA1, Tangier Disease, and Lipid Flopping (Ana Zarubica and Giovanna
Chimini).
Philippe F. Devaux, PhD, is Professor of Physics at the Paris 7 University.He has long-standing expertise in teaching molecular and cellular biophysics and physics applied to biology and medicine. He is the author of almost two hundred scientific papers and three books, and is an Editor of the European Biophysics Journal.
Andreas Herrmann, PhD, is Professor of Molecular Biophysics at Humboldt-University of Berlin. He teaches courses on the subjects of molecular; cell; and membrane biophysics, optical spectroscopy, and fluorescence microscopy. He is the author of more than two hundred scientific papers focusing on lipid dynamics in biological membranes and molecular mechanisms of virus infection.
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