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E-raamat: Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum

Edited by (Professor of Biochemistry, Government College University, Lahore, Pakistan
Professor of Biochemistry, Qassim University, Malidah Al Qa), Edited by , Edited by (Senior Scientist, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 14-May-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128217900
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Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual ContinuumSuurem pilt
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 14-May-2022
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128217900
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Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.

The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.

This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

  • Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers
  • Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field
  • Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and newcomers in the field of cancer metastasis

Arvustused

"This book is an essential resource that provides knowledge about malignant transformation, metastatic spread, and therapeutic outcomes based on integrated genomic, epigenomic, proteomic, and transcriptomic data through easy and comprehensive chapters written by various international experts in the field. The purpose of the book, according to the authors, is to provide very exciting information about the complexities of metastasis to young researchers and distinguished scientists in the field of oncology. These are indeed worthy objectives and the book is very much needed. The book does meet the needs of the intended audience as it covers updated information on the mechanisms of metastasis.... [ Covers] very important details about complexities of metastasis and has several illustrations that enable easy comprehension of a complex subject. This is an excellent book on 'Unraveling the Complexities of Metastasis' and discusses interesting information. [ A] unique [ book] in providing updated information and nanotechnology-based docetaxel therapeutics." --©Doodys Review Service, 2022, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)

List of contributors
ix
Preface xv
1 Role of TRAIL-mediated signaling as Jekyll and Hyde in metastasis: changing places, changing faces
Ammad Ahmad Farooqi
Iqra Moheen
Ruksct Attar
Gamze Tanriover
Introduction
1(2)
Darker side of caspase-8: nonapoptotic caspase-8---mediated functionalities
3(1)
TRAIL-mediated NF-kB activation: friend or foe
4(1)
Concluding remarks
4(1)
References
5(2)
2 Multiple roles of circulating tumor cells and exosomes in cancer metastasis: implications for therapeutic intervention
Chiara Martinelli
List of abbreviations
7(1)
Introduction
8(1)
CTCs involvement in metastatic progression
9(3)
Exosomes involvement in metastatic progression
12(3)
Clinical impact of CTCs and exosomes
15(1)
Conclusions and future perspectives
16(1)
References
17(7)
3 Diagnosis and treatment of metastatic prostate cancer: the role of imaging, liquid biopsies, and biomarkers for deciphering tumor heterogeneity
Xiaoyu Hu
Ryan Gallo
Radka Stoyanova
Adrian L. Breto
Daiki Hara
Junwci Shi
Oleksandr N. Kryvenko
Matthew C. Abramowitz
Alan Dal Pra
Sanoj Punnen
Alan Pollack
Wensi Tao
Introduction
24(1)
Overview of prostate cancer disease states and treatment options
25(5)
Improved imaging and image-guided biopsy for prostate cancer
30(3)
Gene signature panels for prostate cancer risk stratification
33(2)
Next-generation sequencing and prostate cancer: cell-free nucleic acids and circulating tumor cells
35(2)
Conclusion
37(1)
Acknowledgments
37(1)
References
37(12)
4 Prognostic and predictive role of bone metastasis in NSCLC: risk factors and clinical implications
Rossana Berardi
Silvia Rinaldi
Introduction
49(2)
Incidence of BMs in NSCLC patients
51(1)
Prognostic role
51(4)
Predictive role
55(1)
Risk factors for bone metastasis
56(2)
Clinical implication and treatment
58(1)
Conclusion
59(1)
References
60(4)
5 Brain metastases in breast cancer
Maria Luisa Gasparri
Rosa Di Micco
Arianna Siconolfi
Ammad Ahmad Farooqi
Gahrielle Di Bartolomeo
Veronica Zuber
Donatella Gascrta
Filippo Bellati
Ilary Ruscito
Andrea Papadia
Oreste D. Gentilini
Introduction
64(1)
The basis of breast cancer brain metastasis
65(5)
Risk factors for brain metastasis in breast cancer
70(1)
Diagnosis
70(1)
Treatment
71(2)
Prognosis
73(1)
Specific conditions
73(3)
References
76(11)
6 Noncoding way of the metastasis
Bakiye Goker Bagca
Alican Kusoglu
Selin Cesmcli
Cigir Biray Avci
Introduction
87(1)
Dual role of small noncoding RNAs in metastasis
88(1)
Long noncoding RNAs and metastasis
89(8)
Future perspectives
97(1)
References
97(9)
7 Nanotechnology based docetaxel: upcoming avenue for breast cancer management
Indu Pal Kaur
Joga Singh
Sumit Goel
Srishti Jain
Aagamjit Singh
Chitvan Pandit
Prasanna Alturi
Udit Soni
Ravi Pratap Bamwal
Alka Bhatia
Gurpal Singh
Introduction
106(1)
Classification of breast cancer
107(2)
Pathogenesis of breast cancer
109(2)
Causative factors and associated risks of breast carcinoma
111(1)
Mortality
111(1)
Stages of breast cancer
111(1)
Diagnosis
112(1)
Treatment strategies for breast cancer
112(6)
Nanoparticle platforms currently employed or explored clinically in MBC
118(2)
Conclusion
120(1)
Acknowledgment
120(1)
References
120(5)
8 Metastasis in gynecological cancers
Violante Di Donato
Giuseppe Caruso
Giorgia Perniola
Innocenza Palaia
Ludovico Muzii
Pierluigi Benedetti Panici
Introduction
125(1)
Key steps and patterns of metastasis among gynecological cancers
126(1)
Endometrial cancer
127(1)
Cervical cancer
128(1)
Ovarian cancer
128(1)
Vulvar cancer
129(1)
Vaginal cancer
130(1)
Metastasectomy
130(1)
Future directions: targeted therapy
131(1)
Conclusions
132(1)
References
132(6)
9 Regulation of HSP90 by noncoding RNAs in carcinogenesis and metastasis: harbingers of good or evil
Seher Yilmaz
Rukset Attar
Lazzat Karasholakova
Ishmuratova Margarita Yulaevna
Ammad Ahmad Farooqi
Introduction
138(1)
Oncogenic role of HSP90 and miRNAs
138(1)
Tumor suppressive role of HSP90 and miRNAs
138(1)
Targeting of HSP90 by tumor suppressor miRNAs
139(1)
Regulation of HSP90 by IncRNAs
139(1)
Tumor suppressor IncRNAs
139(1)
Partnership of IncRNAs with HSP90 to promote stability of oncogenic proteins: oncogenic role of IncRNAs
140(1)
Partnership of IncRNAs with HSP90 to promote stability of tumor suppressor proteins: tumor suppressor role of IncRNAs
141(1)
LncRNAs protect HSP90 from targeting by miRNAs
141(1)
Regulation of HSP90 by circular RNAs
141(1)
Concluding remarks
142(1)
References
142(3)
10 Role of circular RNAs in carcinogenesis and metastasis: closer analysis of unresolved mysteries
Humaira Naurecn
Rukset Attar
Ilhan Yaylim
Lara Yousscf
Ammad Ahmad Farooqi
Introduction
145(1)
Tumor suppressor circular RNAs
146(3)
Oncogenic role of circular RNAs
149(2)
Concluding remarks
151(1)
References
151(2)
11 Metastatic potential: focus on lipid transport with emphasis on CD36
Laura C. Ccafalan
Andrei M. Niculac
Octavian Loghen
Mihaela Ghcrghiceanu
Mihail E. Hincscu
Introduction
153(1)
Cellular lipids for metastasis---where do they come from?
154(1)
Families of lipid transporters---positioning in classifications
154(4)
Dietary lipids can drive metastasis
158(2)
Supporting cancer cell colonization---pro-survival signalling
160(3)
Signaling via exosomes
163(1)
Low metastatic potential versus high metastatic potential
164(3)
CD36 - a special player?
167(1)
Conclusion
168(1)
Acknowledgments
168(1)
References
169(6)
12 Developmental genes: the bridge between development and cancer metastasis
Tania Cristina Leite de Sampaio e Spohr
Introduction
175(1)
Transforming growth factor beta
176(2)
WNT
178(1)
Sonic hedgehog
179(1)
Notch
180(1)
Fibroblast growth factor
181(1)
Conclusion
182(1)
References
183(4)
13 Heat shock proteins in tumor progression and metastasis
Yusuf Tutar
Humaira Naurccn
Ammad Ahmad Farooqi
Introduction
187(1)
Structure---function relationship of HSPs
188(1)
Role of distinct HSPs in oncogenic progression and in metastasis
189(4)
Epigenetic alterations of HSPs in cancer
193(1)
Posttranslational modifications of HSP90
193(1)
MicroRNA-mediated regulation of heat shock proteins in different cancers
194(1)
Diagnostic, prognostic, and predictive implications of diverse classes of HSP
194(1)
HSP inhibitors
195(1)
Conclusion
195(1)
References
196(8)
14 Role of kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: opposite sides of the same coin
Humaira Naureen
Seda Avnioglu
Seher Yilmaz
Lara Youssef
Ammad Ahmad Farooqi
Introduction
204(1)
Antimetastatic role of KISS1
204(1)
Prometastatic role of kisspeptin-driven signaling
205(1)
Regulation of kisspeptin by noncoding RNAs
205(1)
Concluding remarks
206(1)
References
207(3)
15 Tumor microenvironment manipulation and cancer metastasis (taming the beast)
Yomna Khamis
Waleed Arafat
Introduction
210(1)
Invasion and metastasis
210(1)
The complexity of metastatic colonization
211(1)
The tumor microenvironment
211(1)
Tumor genesis and metastasis
212(1)
Epithelial---mesenchymal transition
212(4)
Relation between epithelial mesenchymal transition and vascularization
216(1)
Component of tumor microenvironment
216(7)
Implication in translational research
223(1)
Targeting TME in therapy
224(2)
Futures research and challenges
226(1)
Understanding TMI for effective immunotherapy
226(1)
References
227(8)
16 Metastasis inhibitory role of hydroxycinnamic acid and its derivatives
Muhammad Javed Iqbal
Maham Fakhar
Tahira Alyas
Ammad Ahmad Farooqi
Introduction
235(2)
Hydroxycinnamic acid
237(1)
Ferulic acid
237(1)
Caffeic acid
237(2)
Concluding remarks
239(1)
References
239(3)
17 Regulatory role of SMURF1 and SMURF2 in metastasis: multitalented SMURFs take the central stage
Ilhan Yaylim
Rukset Attar
Naila Nasir Mahmood
Ammad Ahmad Farooqi
Introduction
242(1)
Prometastatic role of SMURF1
242(1)
Metastasis inhibitory role of SMURF1
243(1)
SMURF2
243(4)
Darker side of SMURF2
247(1)
Concluding remarks
247(1)
References
247(2)
18 Antimetastatic effects of curcumin
Durr-e-shahwar Malik
Tatiana Colombo Pimcntel
Naila Nasir Mahmood
Ammad Ahmad Farooqi
Introduction of curcumin
249(1)
Metastasis inhibitory role of curcumin
250(2)
Curcumin and nanotechnology
252(2)
Concluding remarks
254(1)
References
254(6)
19 Metastasis inhibitory role of blueberries: time to play gooseberry with oncogenic cascades and metastasis
Ammad Ahmad Farooqi
Ulku Ozhey
Tatiana Colombo Pimentel
Rukset Attar
Introduction
260(1)
Inhibition of carcinogenesis and metastasis by different berries: preclinical studies
261(1)
Metastasis inhibitory roles of blueberry
262(1)
Concluding remarks
263(1)
References
263(3)
20 The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behavior
Giovanna Revilla
Antonio Moral
Jose Ignacio Perez
Victoria Fuste
Enrique Lerma
Enma Veronica Paez Espinosa
Josep Julve
Rosa Corcoy
Joan Carles Escola-Gil
Eugenia Mato
Introduction
266(1)
The EMT process in thyroid cancer progression
267(1)
ABC-binding cassette transporters in ETC progression
268(5)
Future perspectives: the ABC transporters and EMT paradigm in ETC
273(1)
Acknowledgments
273(1)
References
273(4)
21 The role of epigenetics in cancer metastasis
Madeline Farmer
Kristina Redd
Tinsley Robcrson
Metta Smith
Kayla Lewis Steed
Introduction
277(2)
DNA methylation and metastasis
279(2)
Histone modifications
281(6)
Noncoding RNA
287(4)
Exosomes and premetastatic niche formation
291(2)
Clinical correlations
293(1)
Conclusions
294(1)
References
294(8)
22 Regulation of angiogenesis in tumor metastasis via Ets-related ERG and micro-RNAs; one hand washes the other
Naila Malkani
Muhammad Usman Rashid
Sidra Mumtaz
Muhammad Imran Sohail
ERG structure
302(1)
ERG functions
303(2)
Crosstalk of ERG with other proteins or signaling cascades
305(1)
ERG regulation
305(5)
ERG can turn the table
310(1)
Conclusion 311(1)
References 312(5)
Index 317
Ammad Ahmad Farooqi is currently serving as a Senior Scientist at Institute of Biomedical and Genetic Engineering (IBGE). His research-work is tightly focused on cell signaling cascades and how these pathways can be therapeutically exploited. He has published more than 200 articles in International peer-reviewed Journals and has guest edited 2 Books. He has over 5000 citations and an H-index above 37. He is editor of various national and international Journals. He has guest edited various thematic issues related to molecular oncology. He has authored/co- authored more than 25 chapters in various books published by internationally distinguished publishers. He was ranked in the top 10 scientists of biological sciences for 2017/2018 by most prestigious national research steering body, Pakistan Council of Science and Technology (PCST). He was ranked in top 2% scientists of the world in the field of oncology in 2019/2020. According to recently published research, he was ranked as No. 1 Scientist in the field of breast cancer research in Pakistan. Muhammad Zahid Qureshi, PhD is a Professor of Biochemistry in Qassim University, Saudi Arabia. He received his PhD from Quaid-i-Azam University Islamabad and post-doctorate from Brunel University, London. He has notable contributions in Biochemistry and Molecular Biology. He has authored/co-authored many articles in international Journals and has published seven chapters. His research is focused on molecular cancer and nanotechnology. Uteuliyev Yerzhan Sabitaliyevich is an academician and reputed scientist from Kazakhstan. He has previously served as a Vice-Rector for academic affairs and research and innovation activities of Kazakhstan Medical University "KSPH". He has notable contributions in scientifically distinguished international journals. He has played key role in inspiring young researchers to make progress in medical field. He has organized series of medical conferences in Kazakhstan to maximize the interaction of local researchers with scientifically eminent researchers from technically advanced countries.
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