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E-raamat: Veterinary Neuropathology: Essentials of Theory and Practice

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(University of California, Davis, USA), (University of Bern, Switzerland), (University of Bern, Switzerland)
  • Formaat: PDF+DRM
  • Ilmumisaeg: 22-Aug-2012
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781118349502
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Veterinary Neuropathology: Essentials of Theory and PracticeSuurem pilt
  • Formaat: PDF+DRM
  • Ilmumisaeg: 22-Aug-2012
  • Kirjastus: Wiley-Blackwell
  • Keel: eng
  • ISBN-13: 9781118349502
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Introducing the theoretical and practical basics of veterinary neuropathology, this concise and well illustrated book is an essential basic diagnostic guide for pathologists, neurologists and diagnostic imaging specialists. It presents readers with strategies to deal with neuropathological problems, showing how to interpret gross and histological lesions using a systematic approach based on pattern recognition.

It starts with an overview of the general principles of neuroanatomy, neuropathological techniques, basic tissue reaction patterns, and recognition of major lesion patterns. The book goes on to cover vascular diseases, inflammatory diseases, trauma, congenital malformations, metabolic-toxic diseases, neoplasia and degenerative diseases mainly of the central nervous system. In the respective chapters pathologists can quickly find information to support their daily diagnostic workup for both small and large domestic species.  Based on the authors extensive diagnostic and post graduate teaching experience as well as the inclusion of MRI as it relates to neuropathology, this book also offers a comprehensive but basic analysis of veterinary neuropathology that neurologists and other MRI users will find very useful.





An essential manual for daily diagnostic work Richly illustrated with high quality colour gross, histological and MRI images Includes a section on the function and use of MRI (by Johann Lang, DECVDI) Accompanied by a website presenting MRI sequences for interpretation and correlation with neuropathological findings edited by Johann Lang (University of Bern, Switzerland) and Eric Wiesner (University of California, Davis, USA) www.wiley.com/go/vandevelde/veterinaryneuropathology

Arvustused

In summary, this is an excellent, well-priced textbook that will be invaluable to practitioners and particularly residents in pathology and neurology training.  (Veterinary Pathology, 1 January 2014)

This book is not only written for specialists but it will help general practitioners understand better the various mechanisms of neurological diseases in many different species. The linked website presents RMI sequences and more neuropathological findings.  (Vets Today, 1 June 2013)

Add color gross, histological and MRI images and you have a key reference any veterinary collection must have.  (Midwest Book Reviews, 1 May 2013)

Thus, Veterinary Neuropathology by Vandevelde, Higgins and Oevermann is an ideal aid for the visual approach to structural lesions of the nervous system. If you are a neurophilic veterinarian, dont leave this book out of your bookshelf unless it has been translocated already to your desk and is open in front of your eyes.  (Veterinary Record, 6 April 2013)

Preface ix
Foreword x
1 General neuropathology
1(37)
1.1 Principles of neuroanatomy for diagnostic neuropathologists
1(10)
1.1.1 Anatomical orientation by using the ventricular system
1(1)
1.1.2 Major anatomical regions of interest
2(5)
1.1.3 Histological neuroanatomy
7(4)
1.2 Neuropathological techniques
11(3)
1.2.1 Necropsy techniques
11(1)
1.2.2 Brain sectioning, macroscopic inspection and sampling for histology
12(2)
1.3 Basic tissue reaction patterns
14(14)
1.3.1 Reactions of neurons to injury
14(6)
1.3.2 Oligodendrocytes
20(1)
1.3.3 Astrocytes
20(2)
1.3.4 Microglia/macrophages
22(1)
1.3.5 CSF spaces
23(1)
1.3.6 Blood vessels
23(1)
1.3.7 Disturbance of water balance: edema
24(2)
1.3.8 Artifacts, postmortem degeneration, pseudolesions and old age
26(2)
1.4 Recognizing major lesion patterns
28(5)
1.4.1 The major lesion patterns
28(3)
1.4.2 Lesion distribution pattern
31(1)
1.4.3 Classification of neurological diseases
31(2)
1.4.4 General strategy
33(1)
1.5 Neuropathology in the clinics: magnetic resonance imaging (MRI)
33(5)
1.5.1 Basic MRI physics
33(1)
1.5.2 Principles of interpretation
34(2)
Further reading
36(1)
Neuropathology general
36(1)
Neurology/functional neuroanatomy
36(1)
Neuroanatomy
37(1)
Techniques for PNS and muscle
37(1)
Basic tissue reaction patterns
37(1)
Edema
37(1)
Artifacts, pseudolesions, old age
37(1)
Magnetic resonance imaging
37(1)
2 Vascular disorders
38(10)
2.1 Pathophysiology of ischemia
38(1)
2.2 General strategy for diagnosing vascular lesions
38(1)
2.3 Common vascular lesions
39(9)
2.3.1 Vascular lesions of the brain
39(5)
2.3.2 Vascular lesions of the spinal cord
44(2)
2.3.3 Ischemia in the peripheral nervous system and muscles
46(1)
Further reading
46(1)
Cerebral infarcts
46(1)
Hemorrhage
46(1)
Hypertensive encehalopathy
46(1)
Fibrocartilagenous emboli
47(1)
Aortic thrombosis
47(1)
3 Inflammatory diseases
48(33)
3.1 Pathophysiology of inflammation
48(2)
3.1.1 Entry and effect of infectious agents in the nervous system
48(1)
3.1.2 Immune reaction of the host against the infectious agent in the CNS
48(1)
3.1.3 Morphological aspects of the immune response
49(1)
3.2 General strategy for diagnosis of inflammatory lesions
50(4)
3.2.1 Recognizing major inflammatory reaction patterns
51(1)
3.2.2 Determining the distribution pattern of the lesions
52(1)
3.2.3 Specific features
52(2)
3.3 Common CNS infections
54(18)
3.3.1 Neurotropic viral infections
54(4)
3.3.2 Viral granulomatous inflammation
58(2)
3.3.3 Viral vasculitis
60(1)
3.3.4 Viral leukoencephalitis
61(2)
3.3.5 Bacterial infections
63(5)
3.3.6 Mycotic and algal infections
68(1)
3.3.7 Protozoal infections
69(1)
3.3.8 Helminth infections
70(2)
3.4 Non-infectious and immune-mediated inflammatory lesions
72(9)
3.4.1 Definition
72(1)
3.4.2 Neurological diseases assumed to be immune-mediated
73(6)
Further reading
79(1)
General
79(1)
Neurotropic viral infections
79(1)
Viral granulomatous infections
79(1)
Viral vasculitis
79(1)
Demyelinating viral infections
79(1)
Bacterial infections
79(1)
Fungal infections
80(1)
Protozoal infections
80(1)
Helminth infections
80(1)
Non-infectious and Immune-mediated inflammatory disorders
80(1)
4 Trauma
81(11)
4.1 Pathophysiology of CNS trauma
81(3)
4.1.1 Pathogenesis of brain trauma
81(1)
4.1.2 Pathogenesis of spinal cord trauma
82(2)
4.2 General strategy for diagnosis of traumatic CNS lesions
84(1)
4.3 Traumatic nervous system diseases
85(7)
4.3.1 Trauma of the brain
85(2)
4.3.2 Traumatic spinal cord lesions
87(2)
4.3.3 Trauma in the peripheral nervous system
89(1)
Further reading
90(1)
Pathophysiology of CNS trauma
90(1)
Brain trauma
91(1)
Intervertebral disc disease
91(1)
Spinal malformations
91(1)
Wobbler syndrome
91(1)
Other causes of cord compression
91(1)
Cauda equina syndrome
91(1)
5 Congenital malformations
92(14)
5.1 Pathophysiology
92(1)
5.1.1 Ontogeny of the CNS
92(1)
5.1.2 Etiology
92(1)
5.2 General strategy for diagnosing anomalies of the CNS
93(1)
5.3 Common malformations
93(13)
5.3.1 Neural tube closure defects
93(1)
5.3.2 Defects of forebrain induction
94(1)
5.3.3 Neuronal migration disorders and sulcation defects
95(1)
5.3.4 Disorders of proliferation or size
96(1)
5.3.5 Encephaloclastic defects
97(1)
5.3.6 Malformations in the caudal fossa and spinal cord
97(3)
5.3.7 Congenital hydrocephalus and other anomalies of CSF pathways
100(4)
Further reading
104(1)
Neural tube closure defects
104(1)
Defects of forebrain induction
104(1)
Neuronal migration disorders and sulcation defects
104(1)
Encephaloclastic defects
104(1)
Cerebellar hypoplasia
104(1)
Dandy Walker syndrome
104(1)
Chiari malformation, Syringomyelia
104(1)
Hydrocephalus
104(1)
Arachnoidal and ependymal cysts
105(1)
6 Metabolic-toxic diseases
106(23)
6.1 General strategy for diagnosis of metabolic-toxic lesions
106(2)
6.1.1 The major patterns
106(1)
6.1.2 Further differential diagnosis
106(2)
6.2 Encephalomalacias/myelomalacias
108(10)
6.2.1 Polioencephalomalacia (PE) or cerebrocortical necrosis (CCN)
108(6)
6.2.2 Polioencephalomalacia of subcortical structures and brainstem
114(1)
6.2.3 Poliomyelomalacia
115(1)
6.2.4 Leukoencephalomalacias
116(1)
6.2.5 Encephalomalacias involving both gray and white matter
117(1)
6.3 Acquired metabolic-toxic selective lesions
118(4)
6.3.1 Neuronal degeneration
118(3)
6.3.2 Axonal degeneration
121(1)
6.3.3 Myelin degeneration
121(1)
6.4 Spongy degeneration
122(2)
6.5 Metabolic-toxic lesions of the peripheral nervous system (PNS) and skeletal muscle
124(5)
6.5.1 Metabolic-toxic neuropathies
125(1)
6.5.2 Metabolic-toxic myopathies
125(1)
Further reading
126(1)
General
126(1)
Polioencephalomalacia large animals
126(1)
Polioencephalomalacia in small animals
126(1)
Hippocampal necrosis and sclerosis
126(1)
Subcortical and brainstem encephalomalacias
126(1)
Selenium poisoning
126(1)
Equine leukomalacia
126(1)
Enterotoxemia
126(1)
CO poisoning
127(1)
Metabolic toxic neuronal degenerations
127(1)
Grass sickness
127(1)
Acquired lysosomal storage diseases
127(1)
Metabolic-toxic axonal degenerations
127(1)
Irradiated feed-induced myelinopathy in cats
127(1)
Toxic spongy degenerations
127(1)
Hepatic encephalopathy
127(1)
Toxic peripheral neuropathies
127(1)
Metabolic peripheral neuropathies
128(1)
Matabolic-toxic myopathies
128(1)
7 Neoplasia
129(28)
7.1 General strategy for diagnosis of neoplastic lesions
129(4)
7.1.1 Clinic and diagnostic imaging
129(1)
7.1.2 Interpretation of gross findings
129(1)
7.1.3 Diagnosis
130(3)
7.1.4 Grading
133(1)
7.2 Tumors of neuroepithelial origin
133(12)
7.2.1 Astrocytomas
133(4)
7.2.2 Oligodendroglioma
137(2)
7.2.3 Mixed gliomas (oligoastrocytomas)
139(1)
7.2.4 Ependymoma
140(2)
7.2.5 Choroid plexus tumors (papillomas and carcinomas)
142(1)
7.2.6 Neuronal and mixed neuronalglial tumors
143(1)
7.2.7 Embryonal tumors
144(1)
7.3 Tumors of cranial and spinal nerves
145(2)
7.3.1 Benign PNST
145(2)
7.3.2 Malignant peripheral nerve sheath tumors (MPNST)
147(1)
7.4 Tumors of the meninges
147(4)
7.4.1 Meningioma
147(3)
7.4.2 Granular cell tumor
150(1)
7.4.3 Mesenchymal tumors
151(1)
7.5 Lymphomas and hematopoietic tumors
151(1)
7.5.1 Primary T and B cell lymphomas
151(1)
7.5.2 Intravascular lymphoma
151(1)
7.5.3 Metastatic lymphoma
152(1)
7.5.4 Primary CNS histiocytic sarcoma
152(1)
7.6 Germ cell tumors
152(1)
7.6.1 Germinoma
152(1)
7.6.2 Teratoma
153(1)
7.7 Embryonal tumors of non-neuroepithelial origin
153(1)
7.7.1 Thoracolumbar spinal cord tumor (ectopic nephroblastoma)
153(1)
7.8 Secondary or metastatic tumors
154(3)
Further reading
155(1)
General
155(1)
Glial tumors
155(1)
Choroid plexus tumors
155(1)
Neuronal tumors
155(1)
Embryonal tumors
155(1)
PNS tumors
155(1)
Meningiomas
155(1)
Granular cell tumor
155(1)
Mesenchymal tumors
155(1)
Lymphomas and hemapoetic tumors
156(1)
Germ cell tumors
156(1)
Nephroblastoma
156(1)
Metastatic tumors
156(1)
8 Degenerative diseases
157(36)
8.1 General strategy for differential diagnosis of degenerative lesions
157(2)
8.1.1 Recognizing the major patterns
157(1)
8.1.2 Further analysis
157(2)
8.1.3 Diagnosis
159(1)
8.2 Degeneration of neurons
159(7)
8.2.1 General aspects
159(1)
8.2.2 Motor neuron diseases
159(3)
8.2.3 Cerebellar degenerations
162(3)
8.2.4 Other neuronal degenerations
165(1)
8.3 Axonal degenerations
166(7)
8.3.1 Wallerian-like degenerative axonopathies
166(5)
8.3.2 Axonopathies with prominent axonal swelling
171(2)
8.4 Myelin disorders
173(5)
8.4.1 Leukodystrophies
173(4)
8.4.2 Myelin dysgenesis
177(1)
8.5 Storage diseases
178(4)
8.5.1 Lysosomal storage diseases
178(3)
8.5.2 Neuronal ceroid lipofucsinoses (NCL)
181(1)
8.5.3 Lafora's disease
181(1)
8.5.4 Acquired lysosomal storage diseases
182(1)
8.6 Spongiform encephalopathies
182(3)
8.6.1 Transmissible degenerative diseases
182(1)
8.6.2 Neuropathology of TSE
183(1)
8.6.3 TSEs in domestic animals
184(1)
8.7 Spongy degenerations
185(2)
8.7.1 Definition and general morphological features
185(1)
8.7.2 Spongy degeneration in branched-chain organic acidurias
186(1)
8.7.3 Spongy degenerations of other causes
187(1)
8.8 Selective symmetrical encephalomalacias (SSE)
187(2)
8.8.1 General morphological features
187(1)
8.8.2 Mitochondrial encephalopathies in people and similar lesions in animals
187(2)
8.9 Degenerative diseases of the peripheral nervous system and muscle
189(4)
8.9.1 Degenerative polyneuropathies
189(1)
8.9.2 Degenerative myopathies
189(1)
Further reading
190(1)
Motor neuron diseases
190(1)
Cerebellar degenerations
190(1)
Other neuronal degenerations
190(1)
Alzheimer disease
190(1)
Wallerian-like axonal degenerations
190(1)
Degenerative myelopathy in old dogs
190(1)
Wallerian-like degeneration in large animals
191(1)
Neuroaxonal dystrophy
191(1)
Leukodystrophies
191(1)
Dysmyelination
191(1)
Lysosomal storage diseases
191(1)
Spongiform encephalopathies
191(1)
Spongy degenerations
191(1)
Selective symmetrical encephalomalacias
192(1)
Degenerative diseases of the PNS and muscles
192(1)
Index 193
Marc Vandevelde Dr.med.vet., DECVN is a professor of neurology in the Division of Neurological Sciences, Vetsuisse Faculty at the University of Bern, Switzerland.

Robert J. Higgins BVSc, MS, PhD, DACVP is a professor of pathology in the Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, at the University of California Davis, Davis, California, USA.

Anna Oevermann Dr. med.vet., DECVP is an associate professor of neuropathology in the Division of Neurological Sciences , Vetsuisse Faculty at the University of Bern, Switzerland.
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