Researchers from academia and biotechnology describe proven molecular methods for the construction, development, and use of virus vectors for gene transfer and gene therapy. Offering detailed step-by-step instructions to ensure successful results, they detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, and other virus systems for vector development and gene transfer, and demonstrate the use of virus vectors in the brain and central nervous system. Each protocol includes a discussion of the principles involved, notes of possible problems, and alternative procedures. Machida is affiliated with the Department of Oral Molecular Biology in the School of Dentistry at Oregon Health & Science University. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Researchers from academia and biotechnology describe proven molecular methods for the construction, development, and use of virus vectors for gene transfer and gene therapy. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system. Comprehensive and highly practical, Viral Vectors for Gene Therapy: Methods and Protocols provides not only researchers with the basic tools needed to design targeted gene delivery vectors, but also clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders.
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