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E-raamat: Vitamin E-Bonded Membrane: A Further Step in Dialysis Optimization.

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Vitamin E-Bonded Membrane: A Further Step in Dialysis Optimization. Suurem pilt
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In recent years, major concerns have been expressed about long-term derangements in hemodialysis patients and possible clinically relevant blood-membrane interactions. Preliminary studies employing biocompatible membranes and antioxidant agents such as vitamin E have demonstrated significant improvements in patient organ function and hemopoietic capacity with increased hematocrit and quality of life. Using a new technology, vitamin E has now been successfully bound to the inner surface of a hollow-fiber membrane, so that the patients blood is flowing in contact with a layer of antioxidant agent covering the inner surface of the membrane in the hemodialyzer. The opening chapters of this publication give an overview on oxidant stress and the role of vitamin E as antioxidant agent and elaborate on technical aspects, hydraulics and permeability characteristics of the membrane in question. The main part is dedicated to the hemocompatibility of the membrane, its effect on erythrocyte morphology and survival and the impact on white cell and platelet function. The metabolic effects and the antioxidant impact of the vitamin E-coated membrane are presented in the last part of the book. Intended as a reference tool for professionals, students and fellows involved in the care of end-stage renal disease patients, it is also hoped that this book serves as a starting point for further speculations and research in the field.
Pathophysiology of the oxidative stress and its implication in uremia
and dialysis; vitamin E as an antioxidant agent; chronic haemolysis and
erythrocyte survival in haemodialysis patients treated with vitamin
E-modified dialysis filters; development of vitamin E-modified membrane;
evaluation of excebrane by infrared imaging; hydraulic and flow dynamic
characteristics of vitamin E-bonded dialyzers; urea clearance and ionic
dialysance of excebrane haemodialyzers; effect of several cellulosic dialytic
membranes on hyperhomocysteinemia and on the oxidative stress in dialysis
patients - any role for curay and vitamin E?; hollow-fiber dialyzer employing
vitamin E-bonded membrane - a morphological analysis; does vitamin E bound on
dialysis membrane improve the LDL susceptibility to oxidation? lessons from
an in vitro model; effect of vitamin E conjugated to dialysis membranes on
immunohaematopoietic cell growth and signalling; effects of vitamin
E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and
removal; lipid peroxidation, leukocyte function and apoptosis in
haemodialysis patients treated with vitamin E-modified filters; morphologic
evaluation of red blood cells using vitamin E-modified dialysis filters;
Excebrane - haemocompatibility studies by the intradialytic monitoring of
oxygen saturation; effect of a new vitamin E-coated membrane on glycoxidation
during haemodialysis; in vivo evaluation of biocompatibility of a new
dialyzer employing the vitamin E-modified cellulose membrane "Excebrane E" -
study of mechanisms involved in mononuclear cell activation; increased red
blood cell survival reduces the need of erythropoietin in haemodialyzed
patients treated with exogenous glutathione and vitamin E-modified membrane;
a chemiluminescence assay for the detection of reactive oxygen species
produced by human neutrophils - in vitro comparison of vitamin E-modified
multilayer haemodialysis filter with a polysulfone dialyzer; immunological
biocompatibility characterization of a vitamin E-bonded membrane; long-term
effects of vitamin E-bonded dialysis membrane on mononuclear cell activation,
malondialdehyde generation and endothelial function in ESRD patients; effect
of vitamin E-modified regenerative cellulose membrane on neutrophil
superoxide anion radical production and lipid peroxidation; suppressive
effects of vitamin E-coated dialysis membrane on haemodialysis-induced
neutrophil activation.
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Püsilink: https://www.kriso.ee/db/97833180045402e.html