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E-raamat: In Vitro Percutaneous Absorption: Principles, Fundamentals, and Applications

(University of California, USA.), (Food & Drug Administration, College Park, Maryland, USA)
  • Formaat: 288 pages
  • Ilmumisaeg: 14-Jun-2023
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781000946628
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In Vitro Percutaneous Absorption: Principles, Fundamentals, and ApplicationsSuurem pilt
  • Formaat: 288 pages
  • Ilmumisaeg: 14-Jun-2023
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781000946628
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This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

This book addresses in vitro percutaneous absorption issues. It also considers many more variables in an in vitro experiment including: diffusion cell design, receptor fluid, preparation of skin, and temperature. The book is useful for both new and experienced investigators to design experiments.
1. Preparation of Human and Animal Skin
2. Diffusion Cell Design
3. A
Flow-Through Diffusion Cell
4. Individual and Regional Variation with In
Vitro Percutaneous Absorption
5. Receptor Fluids
6. Assessment of Vehicle
Factors Influencing Percutaneous Absorption
7. Cutaneous Metabolism
8. Effect
of Occlusion
9. Skin Storage Conditions
10. In Vitro Absorption through
Damaged Skin
11. Localization of Drugs in the Skin
12. Expression of
Absorption Data
13. The LPP Theory of Skin Penetration Enhancement
14. In
Vitro Percutaneous Absorption of Alachlor and Atrazine
15. In Vivo In Vitro
Correlations for Hydrophobic Compounds
16. In Vitro Absorption: Skin Flap
Model
17. Percutaneous Penetration from Soil: Inhibition or Enhancement?
18.
Short-Term In Vitro Skin Exposure
19. Protocol for In Vitro Percutaneous
Absorption Studies
20. Finite Dose In Vitro Percutaneous Permeation Based on
the Diffusion Model: Estimation of Pharmacokinetic Parameters and Prediction
of the Pharmacokinetic Profiles
21. Effect of Sodium Lauryl Sulfate-Induced
Skin Irritation on In Vitro Percutaneous Absorption
Bronaugh\, Robert L.; Maibach\, Howard I.
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