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E-raamat: What's in Your Genome?: 90% of Your Genome Is Junk

  • Formaat: 392 pages
  • Ilmumisaeg: 16-May-2023
  • Kirjastus: Aevo UTP
  • Keel: eng
  • ISBN-13: 9781487538576
  • Formaat - EPUB+DRM
  • Hind: 33,33 €*
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  • Formaat: 392 pages
  • Ilmumisaeg: 16-May-2023
  • Kirjastus: Aevo UTP
  • Keel: eng
  • ISBN-13: 9781487538576

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Whats in Your Genome? describes the functional regions of the human genome, the evidence that 90% of it is junk DNA, and the reasons this evidence has not been widely accepted by the popular press and much of the scientific community.





The human genome contains about 25,000 protein-coding and noncoding genes and many other functional elements, such as origins of replication, regulatory elements, and centromeres. Functional elements occupy only about 10 percent of the more than three billion base pairs in the human genome. Much of the rest is composed of ancient fragments of broken genes, transposons, and viruses. Almost all of this is thought to be junk DNA, based on evidence that dates back fifty years.

This conclusion is controversial. Whats in Your Genome? describes the arguments on both sides of the debate and attempts to explain the reasoning behind those different points of view. The book corrects a number of false narratives that have arisen in recent years and examines how they have affected the debate over junk DNA. In addition, Laurence A. Moran focuses on scientific misconceptions and misinformation and on how the junk DNA controversy has been incorrectly portrayed in both the scientific literature and the popular press. Tracing the earliest indications of junk DNA back to the 1960s, the book explains the success of nearly neutral theory and the importance of random genetic drift, which gave rise to the view that evolution produces sloppy genomes full of junk DNA. Whats in Your Genome? aims to offer the most accurate and current account of the human genome.
Preface vii
Prologue 1(6)
1 Introducing Genomes
7(26)
2 The Evolution of Sloppy Genomes
33(24)
3 Repetitive DNA and Mobile Genetic Elements
57(25)
4 Why Don't Mutations Kill Us?
82(34)
5 The Big Picture
116(20)
6 How Many Genes? How Many Proteins?
136(34)
7 Gene Families and the Birth and Death of Genes
170(22)
8 Noncoding Genes and Junk RNA
192(46)
9 The ENCODE Publicity Campaign
238(26)
10 Turning Genes On and Off
264(33)
11 Zen and the Art of Coping with a Sloppy Genome
297(20)
Notes 317(18)
References 335(24)
Index 359
Laurence (Larry) A. Moran is a professor emeritus in the Department of Biochemistry at the University of Toronto. His main interests are gene expression, genomes, and molecular evolution, and he writes a popular blog called Sandwalk. He has co-authored a number of biochemistry textbooks and maintains a keen interest in science education.