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E-raamat: Fish Physiology: Zebrafish

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  • Sari: Fish Physiology
  • Ilmumisaeg: 23-Jun-2010
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780080961378
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  • Formaat: PDF+DRM
  • Sari: Fish Physiology
  • Ilmumisaeg: 23-Jun-2010
  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780080961378

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Physiologists and other integrative biologists have embraced the zebrafish as a powerful model organism to study research topics as diverse as cardio-respiratory function, neurobiology, toxicology and even human disease. This volume, aptly titled Zebrafish, is the first comprehensive compilation of chapters outlining the physiology of this extensively studied and fascinating animal. Zebrafish will serve as a one-stop resource not only for traditional fish physiologists but also for biomedical researchers, toxicologists and developmental biologists. The subject areas covered in this volume represent key domains of modern physiological research, which include endocrinology, respiration, cardiovascular function, ionic and acidbase regulation, neurobiology, hearing and vision. In addition to chapters on fundamental physiological systems, this book will summarize the tools used to study zebrafish physiology and the applicability of zebrafish for studies of human disease and aquatic toxicology. This authoritative review, which represents the contributions of the world's leading researchers, is destined to emerge as the single most important resource for students and researchers seeking information on zebrafish.

Arvustused

"This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists an developmental biologists." --GrrlScientists Maniraptora blog on Nature.com

Muu info

A one-stop resource for referencing zebrafish research that integrates and synthesizes all aspects of zebrafish biology in one location
Contributors ix
Preface xi
1 Genetic Tools
Marc Ekker
Marie-Andree Akimenko
1 Introduction
2(1)
2 Forward Genetics: From Large Screens to Targeted Screens
3(1)
3 Reverse Genetics: Morpholino Knockdowns
4(4)
4 Reverse Genetics: TILLING
8(2)
5 Reverse Genetics: Zinc Finger Nucleases
10(3)
6 Gain of Function: Targeted Misexpression of Genes
13(3)
7 Genetic Ablation of Specific Cell Population
16(2)
8 Concluding Remarks
18(8)
2 Organization and Physiology of the Zebrafish Nervous System
Laure Bally-Cuif
Philippe Vernier
1 Introduction
26(3)
2 Nervous System Development and General Organization
29(6)
3 General Organization of the Zebrafish Nervous System, Subdivisions and Main Functions
35(9)
4 The Peripheral Nervous System
44(3)
5 Sensory Systems
47(3)
6 Motor Systems and Integrative Centers
50(1)
7 Monoaminergic and Related Regulatory Systems
51(4)
8 Emotions and Cognition
55(7)
9 Nervous System Plasticity
62(20)
3 Zebrafish Vision: Structure and Function of the Zebrafish Visual System
Stephan C. F. Neuhauss
1 Visual Ecology
82(1)
2 Structure of the Visual System
82(13)
3 Retinal Projections
95(2)
4 Optic Tectum
97(2)
5 Visual Behavior
99(10)
6 Complex Visual Behavior
109(2)
7 Concluding Remarks
111(13)
4 The Zebrafish Inner Ear
Leila Abbas
Tanya T. Whitfield
1 Introduction
124(3)
2 Development of the Inner Ear
127(7)
3 Generation and Homeostasis of Endolymph in the Zebrafish Inner Ear
134(3)
4 Zebrafish Sensory Hair Cells
137(4)
5 Mechanotransduction
141(3)
6 Neural Activity
144(3)
7 Otoliths
147(9)
8 Adult Hearing
156(4)
9 Concluding Remarks
160(14)
5 Endocrinology of Zebrafish: A Small Fish with a Large Gene Pool
Ellen R. Busby
Graeme J. Roch
Nancy M. Sherwood
1 Introduction
174(1)
2 Reproduction
175(37)
3 Stress: The Cortisol Stress Axis
212(2)
4 Growth
214(7)
5 Thyroidal Regulation
221(2)
6 Energy Homeostasis: Food Intake and Metabolism
223(6)
7 Osmoregulation
229(3)
8 Summary
232(18)
6 Developmental Physiology of the Zebrafish Cardiovascular System
John D. Mably
Sarah J. Childs
1 Cardiovascular Disease: Models Wanted
250(1)
2 Current Models for Cardiovascular System Studies
251(1)
3 Filling a Niche with Zebrafish
252(1)
4 Unique Advantages of the Zebrafish for Cardiovascular Studies
252(1)
5 Vertebrate Cardiac Development
253(1)
6 Origin and Lineage of Cells in the Cardiovascular System
253(1)
7 Zebrafish Genetics and Development of the Cardiovascular System
254(1)
8 Genetic Infrastructure and Tools for Zebrafish Studies
255(1)
9 Zebrafish Cardiovascular Mutants
255(3)
10 Mutants Affecting Rate, Rhythm and Contractile Properties of the Heart
258(2)
11 Relationship Between Cardiovascualr Function and Form
260(1)
12 Endothelial Cell Specification and Differentiation
261(1)
13 Specification of Artery and Vein
261(2)
14 Cell Migration of Angioblasts and Vascular Patterning
263(1)
15 Angiogenesis of the Intersegmental Vessels
264(1)
16 Lumenization of Vessels
264(1)
17 Vascular Stabilization, Mural Cells, and Extracellular Matrix
265(1)
18 Angiogenesis of Organs
266(2)
19 Chemical Biology Approaches to Study Cardiovascular Biology
268(1)
20 Forces that Influence Cardiovascular Development
269(4)
21 Endothelial Cell Survival
273(1)
22 Zebrafish Models for Vascular Anomalies
273(1)
23 Tools for the Study of Cardiovascular Physiology
274(1)
24 Vessel Regeneration
275(1)
25 Cardiac Regeneration
276(1)
26 Summary
277(13)
7 Respiration
Bernd Pelster
Brian Bagatto
1 Introduction
290(1)
2 The Principles of Gas Exchange
291(2)
3 The Site of Gas Exchange
293(3)
4 Convective Transport
296(3)
5 Metabolic Activity
299(2)
6 Hypoxic Effects
301(2)
7 Temperature Effects
303(2)
8 Future Perspectives
305(7)
8 Ionic and Acid---Base Regulation
Pung-Pung Hwang
Steve F. Perry
1 Introduction
312(1)
2 Identification of Ionocytes in Skin/gills
313(2)
3 Sodium Uptake and Acid Secretion by Skin/gills
315(5)
4 Chloride Uptake and Base Excretion
320(2)
5 Calcium Uptake
322(1)
6 Ammonia Excretion
323(2)
7 Differentiation and Functional Regulation of Ionocytes
325(5)
8 Neuroendocrine Control of Ion Uptake and Acid-Base Regulation
330(2)
9 Renal Ionic and Acid Base Regulation
332(2)
10 Conclusions and Perspectives
334(12)
9 The Zebrafish as a Model for Human Disease
Cong Xu
Leonard I. Zon
1 Introduction
346(1)
2 Cancer
347(5)
3 Hematopoictic Disorders
352(5)
4 Cardiovascular Diseases
357(2)
5 Chemical Screening in Zebrafish
359(3)
6 Summary
362(6)
10 Perspectives on Zebrafish as a Model in Environmental Toxicology
John J. Stegeman
Jared V. Goldstone
Mark E. Hahn
1 Introduction
368(2)
2 Current Issues in Environmental Toxicology
370(3)
3 The Zebrafish Toxicology Landscape: Emergence of a New Model
373(2)
4 Molecular Environmental Toxicology: The Defensome Concept
375(19)
5 Advances and Insights with Zebrafish
394(12)
6 Toxicity and Environmental Assessment with Zebrafish
406(5)
7 Areas of Looming Significance and Promising Approaches
411(8)
8 Some Conclusions
419(22)
Index 441(12)
Other Volumes in the Fish Physiology Series 453
Dr. Tony Farrell is a Professor Emeritus in the Department of Zoology & Faculty of Land and Food Systems at the University of British Columbia and a Fellow of the Royal Society of Canada. His research had provided an understanding of fish cardiorespiratory systems and has applied this knowledge to salmon migratory passage, fish stress handling and their recovery, sustainable aquaculture and aquatic toxicology. He has over 490 research publications in peer-reviewed scientific journals and an h-factor of 92. He has co-edited of 30 volumes of the Fish Physiology series, as well as an award-winning Encyclopedia of Fish Physiology. As part of his application of physiology to aquaculture, he has studied the sub-lethal impacts of sea lice and piscine orthoreovirus on the physiology of juvenile salmon. Dr. Farrell has received multiple awards, including the Fry Medal, which is the highest honour to a scientist from the Canadian Society of Zoologists, the Beverton Medal, which is the highest honour to a scientist from the Fisheries Society of the British Isles, the Award of Excellence, which is the highest honour of the American Fisheries Society and the Murray A. Newman Awards both for Research and for Conservation from the Vancouver Marine Sciences Centre. He is a former President of the Society of Experimental Biologists and a former Editor-in-Chief for the Journal of Fish Biology. He served as a member of the Ministers Aquaculture Advisory Committee on Finfish Aquaculture for British Columbia and was a member of the Federal Independent Expert Panel on Aquaculture Science. Dr. Colin Brauner was educated in Canada at the University of British Columbia (Ph D), followed by a Post-doctoral fellowship at Aarhus University and the University of Southern Denmark, and was a Research Associate at McMaster University. He is a Professor of Zoology, UBC and Director of the UBC Aquatics Facility. He has been a Co-Editor of the Fish Physiology series since 2006. His research investigates environmental adaptations (both mechanistic and evolutionary) in relation to gas-exchange, acid-base balance and ion regulation in fish, integrating responses from the molecular, cellular and organismal level. The ultimate goal is to understand how evolutionary pressures have shaped physiological systems among vertebrates and to determine the degree to which physiological systems can adapt/acclimate to natural and anthropogenic environmental changes. This information is crucial for basic biology and understanding the diversity of biological systems, but much of his research conducted to date can also be applied to issues of aquaculture, toxicology and water quality criteria development, as well as fisheries management. His achievements have been recognized by the Society for Experimental Biology, UK (Presidents medal) and the Canadian Conference for Fisheries Research (J.C. Stevenson Memorial Lecturer) and the Vancouver Marine Sciences Centre (Murray A. Newman Award for Aquatic Research). He is a former President of the Canadian Society of Zoologists.