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E-raamat: Handbook of Mitochondrial Dysfunction

Edited by (Nottingham Trent University, United Kingdom)
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 15-May-2019
  • Kirjastus: CRC Press
  • Keel: eng
  • ISBN-13: 9780429811760
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 15-May-2019
  • Kirjastus: CRC Press
  • Keel: eng
  • ISBN-13: 9780429811760

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Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.

Key Features











Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.





Includes summary of both causes and effects of these diseases.





Discusses current and potential future therapies for mitochondrial dysfunction diseases





Explores a wide variety of diseases caused by dysfunctional mitochondria.

Arvustused

"This book presents a compilation of the current knowledge associated with mitochondrial dysfunction. Although titled as a handbook, it represents a textbook that covers multiple aspects of the role of mitochondria in human disease. It is an extensive and detailed review of the biological importance of mitochondria." - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital

Preface xi
Acknowledgment xiii
About the Editor xv
Contributors xvii
Section I Introduction: Structure and Function of Mitochondria
Chapter 1 Mitochondrial Structure and Function
3(6)
Marcos Roberto de Oliveira
Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria
9(14)
Puja Agarwal
Mehali Mitra
Sujit Roy
Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair
23(16)
Kalyan Mahapatra
Sayanti De
Sujit Roy
Section II Mitochondrial Dysfunction and Diseases
Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases
39(16)
Katarzyna Totiska
Chapter 5 Kearns-Sayre Syndrome
55(6)
Josef Finsterer
Chapter 6 Mitochondrial Dysfunction and Barth Syndrome
61(18)
Arianna F. Anzmann
Steven M. Claypool
Hilary Vernon
Chapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer's Disease
79(8)
Isaac G. Onyango
Chapter 8 Mitochondrial Dysfunction in Multiple Sclerosis
87(6)
Angela Dziedzic
Elzbieta Miller
Joanna Saluk-Bijak
Michal Bijak
Chapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease
93(10)
Maria V. Irazabal
Alfonso Eirin
Chapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to Clinical Therapeutics
103(12)
Thalita Basso Scandolara
Leticia Madureira Pacholak
Thayse Fachin Cormanique
Rodrigo Kern
Carolina Panis
Chapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis
115(12)
Silvio Zaina
Gertrud Lund
Chapter 12 Mitochondrial Dysfunction and Heart Diseases
127(16)
Dao-Fu Dai
Chapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer
143(8)
Jan Jezek
Chapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma
151(12)
Naveen K. Bhatraju
Anurag Agrawal
Chapter 15 Mitochondrial Dysfunction and Hearing Loss
163(8)
Maria de la Luz Arenas Sordo
Chapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases
171(20)
Jahaun Azadmanesh
Gloria E.O. Borgstahl
Chapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction and Human Brain Pathologies
191(14)
Vismaya
Yogachar Chithra
Muchukunte Mukunda Srinivas Bharath
Chapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis
205(12)
Pu Duann
Elias A. Lianos
Pei-Hui Lin
Chapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury
217(14)
David Blitzer
Borami Shin
Alvise Guariento
Pedro J. del Nido
James D. McCully
Chapter 20 Mitochondrial Dysfunction in Diabetes
231(12)
Eric L. Johnson
Chapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood
243(22)
Martin Magner
Chapter 22 Mitochondrial Dysfunction and Epilepsies
265(12)
Bindu Parayil Sankaran
Arun B. Taly
Chapter 23 Mitochondrial Dysfunction and Allergic Disease
277(16)
Kritika Khanna
Anurag Agrawal
Section III Factors Affecting Mitochondrial Function
Chapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria
293(16)
Marcos Roberto de Oliveira
Chapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle
309(10)
Teet Seene
Chapter 26 The Effects of Resveratrol on the Brain Mitochondria
319(16)
Marcos Roberto de Oliveira
Chapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise
335(6)
Sergej M. Ostojic
Chapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations
341(20)
Carlos Ortez
Andres Nascimento
Chapter 29 Mitochondrial Stress and Cellular Senescence
361(18)
Irene L. Tan
Michael C. Velarde
Chapter 30 Role of Mitochondrial Dysfunction in Human Obesity
379(10)
David Albuquerque
Sara Carmo-Silva
Daniel Alvarez-Vaca
Celia Aveleira
Clevio Nobrega
Chapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells
389(10)
Feres Jose Mocayar Martin
Emiliano Diez
Russel J. Reiter
Walter Manucha
Chapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy and Avenues for Therapy
399(10)
Jennifer Jossart
Taylor N. Dennis
J. Jefferson
P. Perry
Chapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome
409(16)
Qiaozhu Su
Hao Wang
Section IV Immunity and Toxicity
Chapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics
425(18)
Mohsin Khan
Hasan Imam
Saiful Anam Mir
Chapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments
443(18)
Elise Jacquin
Eric Hervouet
Michael Boyer-Guittaut
Chapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption
461(10)
Alan J. Hargreaves
Chapter 37 Mitochondrial Dysfunction in Friedreich Ataxia
471(6)
Rosella Abeti
Annalisa Baccaro
Paola Giunti
Index 477
Shamim I. Ahmad earned his

Masters degree in Botany from

Patna University, Bihar, India, and

his PhD in Molecular Genetics

from Leicester University, England.

He then joined Nottingham

Polytechnic as a grade 1 lecturer and subsequently was

promoted to the post of Senior Lecturer. Ahmad now

spends much of his time producing/writing medical

books. For more than three decades he researched different

areas of molecular biology/genetics including thymineless

death in bacteria, genetic control of nucleotide

catabolism, development of anti-AIDs drug, control of

microbial infection of burns, phages of thermophilic bacteria,

and microbial flora of Chernobyl after the nuclear

power station accident. But his main interest is DNA

damage and repair specifically by near-ultraviolet light

mostly through the photolysis of biological compounds,

production of reactive oxygen species, and their implications

on human health including skin cancer. He also

investigates near-ultraviolet photolysis of non-biological

compounds such as 8-metoxypsoralen, mitomycin C, and

their importance in psoriasis treatment and in Fanconi

anemia. He has collaborated with the University of

Osaka, Japan, and he and his colleagues were able to

show that a number of naturally occurring enzymes were

able to scavenge the reactive oxygen species.

In 2003 he received a prestigious Asian Jewel Award

in Britain for Excellence in Education. His long time ambition

to produce medical books started in 2007 and since

then he has published Molecular mechanisms of Fanconi

Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;

Molecular Mechanisms of Cockayne Syndrome;

Molecular Mechanisms of Ataxia Telangiectasia; Diseases

of DNA repair; Neurodegenerative diseases; Diabetes: an

Old Disease a New Insight, Obesity: a Practical Guide,

Thyroid: Basic Science and Clinical Practice, and Ultraviolet

light in Human Health, diseases and environment; also

as a co-author the book on Diabetes: A comprehensive

Treatise for patients and Caregivers. His most recent books

are Reactive Oxygen Species in Biology and Human Health

and Aging: Exploring a Complex Phenomenon.