| Foreword |
|
v | |
|
|
|
xvii | |
|
|
|
1 | (234) |
|
Introduction: The Evolution of Intracellular Life Forms and their Niches |
|
|
3 | (18) |
|
|
|
|
|
A Short History of Theories and Discoveries |
|
|
3 | (2) |
|
A Look Through the Microscope of Evolution |
|
|
5 | (4) |
|
Continuous Exchange of Information |
|
|
9 | (1) |
|
Evolution of Intracellular Parasitism |
|
|
10 | (3) |
|
Intracellular Symbionts: Tamed or Acclimatized Parasites? |
|
|
13 | (1) |
|
An Ecological View of Intracellular Life |
|
|
14 | (2) |
|
|
|
16 | (1) |
|
|
|
17 | (1) |
|
|
|
18 | (3) |
|
|
|
18 | (3) |
|
Limited Genomes and Gene Transfer in the Evolution of Intracellular Parasitism and Symbiosis |
|
|
21 | (16) |
|
|
|
|
|
Introduction to Gene Transfer and Evolution |
|
|
21 | (2) |
|
Gene Transfer in Intracellular Bacterial Parasites |
|
|
23 | (4) |
|
Gene Transfer in Intracellular Symbionts |
|
|
27 | (2) |
|
Gene Transfer in Intracellular Parasites and Fungi |
|
|
29 | (1) |
|
|
|
30 | (7) |
|
|
|
32 | (5) |
|
Phagocytosis: Early Events in Particle Recognition and Uptake |
|
|
37 | (28) |
|
|
|
|
|
Phagocytosis: An Overview |
|
|
37 | (1) |
|
Recognition of Target Particles |
|
|
38 | (4) |
|
Signaling Events Upon Ligand Recognition |
|
|
42 | (4) |
|
Membrane Dynamics During Phagocytosis |
|
|
46 | (2) |
|
|
|
48 | (2) |
|
Inflammatory Signals Linked to Phagocytosis |
|
|
50 | (2) |
|
|
|
52 | (13) |
|
|
|
52 | (13) |
|
Cellular Model Systems Used to Study Phagosome Biogenesis |
|
|
65 | (12) |
|
|
|
From Grazing to Host Defense |
|
|
65 | (1) |
|
Dictyostelium, a Professional Phagocyte at the Border of Multicellularity |
|
|
66 | (1) |
|
Dictyostelium, a Surrogate Host for Legionella, Mycobacterium and Other Pathogens |
|
|
67 | (3) |
|
Legionella-directed Phagosome Biogenesis |
|
|
70 | (2) |
|
The Whole Animal Model Drosophila melanogaster |
|
|
72 | (1) |
|
Infection of Drosophila Phagocytes |
|
|
73 | (1) |
|
|
|
74 | (3) |
|
|
|
75 | (2) |
|
Methods Used to Study Phagosome Biogenesis |
|
|
77 | (18) |
|
|
|
Describing the World Within - Whole-Cell Assays for Phagosome Contents |
|
|
77 | (10) |
|
Biochemical Analysis and Assays with Purified Phagosomes |
|
|
87 | (1) |
|
Use of Fluorescence-Activated Cell Sorting (FACS) in Phagosome Research |
|
|
88 | (1) |
|
Knockdown, Knockout and Phagosome Research |
|
|
89 | (1) |
|
Transcriptomics as a Phagosome Environmental Sensor |
|
|
90 | (5) |
|
|
|
91 | (4) |
|
In Vitro Fusion Assays with Phagosomes |
|
|
95 | (12) |
|
|
|
|
|
|
|
95 | (1) |
|
|
|
96 | (5) |
|
Studying Normal Maturation... |
|
|
101 | (2) |
|
... and the Pathogenic Case |
|
|
103 | (4) |
|
|
|
105 | (2) |
|
Phagosome Proteomes Unite! A Virtual Model of Maturation as a Tool to Study Pathogen-Induced Changes |
|
|
107 | (18) |
|
|
|
|
|
|
|
107 | (1) |
|
A Methods Guide to Phagosome Proteomics |
|
|
108 | (4) |
|
Particle-Induced Impact on Phagosome Isolation |
|
|
112 | (1) |
|
Comparative Proteomics of Microbe-Containing Vacuoles |
|
|
113 | (8) |
|
|
|
121 | (4) |
|
|
|
122 | (3) |
|
Phagosome-Cytoskeleton Interactions |
|
|
125 | (20) |
|
|
|
|
|
|
|
125 | (1) |
|
The Actin Cytoskeleton. General Background |
|
|
126 | (10) |
|
The Microtubule Cytoskeleton - General Background |
|
|
136 | (4) |
|
|
|
140 | (5) |
|
|
|
140 | (5) |
|
Intracellular Microbe Whole-Genome Expression Profiling: Methodological Considerations and Biological Inferences |
|
|
145 | (14) |
|
|
|
|
|
|
|
145 | (1) |
|
Methodological Considerations |
|
|
146 | (3) |
|
Biological Inferences from Expression Profiling |
|
|
149 | (6) |
|
|
|
155 | (4) |
|
|
|
156 | (3) |
|
Everybody Has A Home of Their Own - ``The Phagosome Zoo'' |
|
|
159 | (32) |
|
|
|
Come On In, Get Killed! Death in the Shredder |
|
|
159 | (4) |
|
Professionals and Laypersons |
|
|
163 | (2) |
|
Come On In, Have Fun! Life in a Golden Cage |
|
|
165 | (19) |
|
Immune Activation and the Loss of Home |
|
|
184 | (1) |
|
Why Not Pathogens in Peroxisomal Vacuoles? |
|
|
185 | (1) |
|
|
|
186 | (1) |
|
|
|
186 | (5) |
|
|
|
187 | (4) |
|
Consequences of Pathogen Compartmentation for Therapeutic Intervention |
|
|
191 | (12) |
|
|
|
|
|
|
|
191 | (1) |
|
Consequences of Intracellular Localization for Treatment with Antibiotics |
|
|
191 | (4) |
|
Many Roads Lead Into the Host Cell |
|
|
195 | (2) |
|
|
|
197 | (1) |
|
``Small Molecules'' Pave the Road to the Future |
|
|
197 | (1) |
|
How Do You Come Up With A Successful ``Small Molecule?'' |
|
|
198 | (1) |
|
A Few More, Maybe Even Practicable, Ideas For the Future... |
|
|
199 | (4) |
|
|
|
200 | (3) |
|
The Immune Response to Intracellular Pathogens |
|
|
203 | (32) |
|
|
|
|
|
|
|
203 | (3) |
|
|
|
206 | (11) |
|
|
|
217 | (13) |
|
|
|
230 | (1) |
|
Excursus - Immunity in Plants |
|
|
230 | (5) |
|
|
|
232 | (3) |
|
Part II Selected Pathogens |
|
|
235 | (1) |
|
|
|
235 | (156) |
|
|
|
237 | (18) |
|
|
|
|
|
Introduction of Afipia felis and its Role in Cat Scratch Disease |
|
|
237 | (3) |
|
Uptake and Intracellular Compartmentation of Afipia felis in Murine Macrophages |
|
|
240 | (2) |
|
The Port of Entry Paves the Way for Non-Endocytic Compartmentation |
|
|
242 | (8) |
|
Host and Pathogen Determinants Involved in Diverted Phagosome Biogenesis |
|
|
250 | (1) |
|
Immunology of the Afipia-Containing Phagosome |
|
|
251 | (1) |
|
|
|
252 | (3) |
|
|
|
253 | (2) |
|
|
|
255 | (18) |
|
|
|
|
|
|
|
|
|
255 | (3) |
|
Characterization of Intra-Host Cell Compartmentation of Brucella and its Relationship to Virulence |
|
|
258 | (4) |
|
Factors Involved in Diverted Phagosome Maturation and Compartment Maintenance |
|
|
262 | (4) |
|
Immunology of Phagosomes Containing Brucella |
|
|
266 | (3) |
|
|
|
269 | (4) |
|
|
|
270 | (3) |
|
|
|
273 | (14) |
|
|
|
|
|
273 | (1) |
|
Characterization of the Chlamydial Inclusion and its Relationship to Virulence |
|
|
273 | (2) |
|
Genes Involved in Chlamydial Inclusion Maturation |
|
|
275 | (6) |
|
Immunology of the Chlamydial Inclusion |
|
|
281 | (2) |
|
|
|
283 | (4) |
|
|
|
283 | (4) |
|
|
|
287 | (14) |
|
|
|
|
|
|
|
Coxiella burnetii and Q Fever |
|
|
287 | (1) |
|
Characterization of the Intrahost Compartment of Coxiella and its Relationship to Virulence |
|
|
288 | (7) |
|
Genes Involved in Diverted Phagosome Maturation/Compartment Maintenance |
|
|
295 | (2) |
|
Immunology of the Coxiella Parasitophorous Vacuole |
|
|
297 | (1) |
|
|
|
297 | (4) |
|
|
|
298 | (3) |
|
|
|
301 | (14) |
|
|
|
Ehrlichia and Anaplasma and the Illnesses They Cause in Humans |
|
|
301 | (1) |
|
Characterization of Host Cell Compartmentalization of E. chaffeensis and A. phagocytophilum |
|
|
302 | (8) |
|
Microbe Genes Involved in Subverting Phagosome Maturation/Compartment Maintenance |
|
|
310 | (1) |
|
Immunology of Phagosomes Containing E. chaffeensis and A. phagocytophilum |
|
|
311 | (1) |
|
|
|
312 | (3) |
|
|
|
312 | (3) |
|
|
|
315 | (12) |
|
|
|
|
|
Legionella pneumophila Biology |
|
|
315 | (1) |
|
The Intracellular Compartment of L. pneumophila |
|
|
315 | (1) |
|
Requirements for Intracellular Replication |
|
|
316 | (4) |
|
The Immune Response to L. pneumophila Infection |
|
|
320 | (2) |
|
|
|
322 | (5) |
|
|
|
323 | (4) |
|
Mycobacterium tuberculosis and His Comrades |
|
|
327 | (28) |
|
|
|
|
|
327 | (5) |
|
Intracellular Compartment and Virulence Properties of Mycobacteria |
|
|
332 | (14) |
|
Host Response and Transmission |
|
|
346 | (2) |
|
|
|
348 | (7) |
|
|
|
349 | (6) |
|
Rhodococcus equi and Nocardia asteroides |
|
|
355 | (18) |
|
|
|
|
|
Rhodococcus and Nocardia and Illnesses Caused by them |
|
|
355 | (2) |
|
Characterization of Intra-Host Cell Compartmentation and its Relationship to Virulence |
|
|
357 | (4) |
|
Genes Involved in Diverted Phagosome Maturation or Compartmentation and its Maintenance |
|
|
361 | (3) |
|
Immunology of Phagosomes Containing R. equi or N. asteroides |
|
|
364 | (3) |
|
|
|
367 | (6) |
|
|
|
368 | (5) |
|
|
|
373 | (18) |
|
|
|
|
|
373 | (3) |
|
Characterization of the SCV and its Role in Virulence |
|
|
376 | (2) |
|
Factors Affecting SCV Biogenesis |
|
|
378 | (5) |
|
|
|
383 | (1) |
|
|
|
384 | (7) |
|
|
|
384 | (7) |
|
II B Intracytosolic Bacteria |
|
|
391 | (114) |
|
Burkholderia pseudomallei |
|
|
393 | (22) |
|
|
|
|
|
Burkholderia pseudomallei and Melioidosis |
|
|
393 | (1) |
|
An Overview of the Intracellular Life of B. pseudomallei |
|
|
394 | (1) |
|
Genome Structure and Diversity of B. pseudomallei |
|
|
395 | (1) |
|
Cell Contact and Adherence |
|
|
396 | (2) |
|
|
|
398 | (2) |
|
|
|
400 | (1) |
|
|
|
401 | (3) |
|
|
|
404 | (1) |
|
Intracellular Replication |
|
|
405 | (1) |
|
Immunology of B. pseudomallei-Host Cell Interactions |
|
|
406 | (1) |
|
|
|
407 | (1) |
|
|
|
408 | (7) |
|
|
|
415 | (16) |
|
|
|
|
|
Francisella tularensis and Tularemia |
|
|
415 | (1) |
|
F. tularensis Inhibits Phagosome Maturation Prior to Egress and Replication in the Cytosol |
|
|
416 | (6) |
|
F. tularensis Virulence Factors that Disrupt Phagocyte Function |
|
|
422 | (2) |
|
Immunology of Phagosome and Host Defense |
|
|
424 | (1) |
|
|
|
424 | (7) |
|
|
|
425 | (6) |
|
|
|
431 | (24) |
|
|
|
|
|
|
|
431 | (4) |
|
The Intracellular Lifestyle of Listeria and its Relationship to Virulence |
|
|
435 | (6) |
|
Bacterial Factors Involved in Escape From the Vacuole |
|
|
441 | (5) |
|
Survey Inside the Phagosome and Phagosome Maturation |
|
|
446 | (5) |
|
|
|
451 | (4) |
|
|
|
452 | (3) |
|
|
|
455 | (14) |
|
|
|
|
|
An Introduction to Mycobacterium marinum and the Illness Caused by it |
|
|
455 | (3) |
|
Characterization of Intra-Host Cell Compartmentation of M. marinum and its Relationship to Virulence |
|
|
458 | (3) |
|
Genes Involved in Diverting Phagosome Maturation and in Compartment Maintenance |
|
|
461 | (2) |
|
Immunological Aspects of M. marinum Infection |
|
|
463 | (1) |
|
What's Next? (Outlook and Summary) |
|
|
464 | (5) |
|
|
|
465 | (4) |
|
|
|
469 | (16) |
|
|
|
|
|
|
|
Introduction to Rickettsiae and Rickettsial Diseases |
|
|
469 | (3) |
|
Intracytoplasmic Behavior of Rickettsiae |
|
|
472 | (5) |
|
Host Cell Interactions with Pathogenic Rickettsia Species |
|
|
477 | (2) |
|
Animal Models and Immunology of Rickettsioses |
|
|
479 | (1) |
|
Genomics and Proteomics of Rickettsia Species |
|
|
480 | (2) |
|
|
|
482 | (3) |
|
|
|
483 | (2) |
|
|
|
485 | (20) |
|
|
|
|
|
|
|
485 | (3) |
|
Escape into the Cytoplasm and Intracytoplasmic Replication |
|
|
488 | (5) |
|
Genes Involved in Phagosome Escape and Intracytoplasmic Life |
|
|
493 | (3) |
|
Host Defense Against Cytoplasmic Shigella |
|
|
496 | (3) |
|
|
|
499 | (6) |
|
|
|
499 | (6) |
|
II C Intracellular Symbionts |
|
|
505 | (60) |
|
Bacterial Symbionts of Plants |
|
|
507 | (20) |
|
|
|
|
|
|
|
Introduction to Rhizobia and Symbioses |
|
|
507 | (1) |
|
Invasion of Plant Cells by Rhizobia and Arbuscular Mycorrhizae |
|
|
508 | (2) |
|
Plant Genes Involved in Symbiosis Initiation |
|
|
510 | (4) |
|
Symbiotic Signals Produced by Rhizobia |
|
|
514 | (7) |
|
|
|
521 | (6) |
|
|
|
521 | (6) |
|
Cyanobacterial and Algal Symbioses |
|
|
527 | (20) |
|
|
|
|
|
|
|
|
|
527 | (1) |
|
Intracellular Cyanobacteria |
|
|
527 | (9) |
|
|
|
536 | (11) |
|
|
|
543 | (4) |
|
|
|
547 | (18) |
|
|
|
|
|
|
|
547 | (3) |
|
Mutualistic Primary Endosymbionts with a Function in Nutritional Upgrading |
|
|
550 | (4) |
|
Endosymbionts that Interfere with Reproduction |
|
|
554 | (4) |
|
|
|
558 | (1) |
|
Conclusion and Future Directions |
|
|
559 | (6) |
|
|
|
560 | (5) |
|
|
|
565 | (124) |
|
|
|
567 | (16) |
|
|
|
Histoplasma capsulatum and Histoplasmosis |
|
|
567 | (2) |
|
Characterization of the Macrophage Phagosomes Containing H. capsulatum Yeasts |
|
|
569 | (4) |
|
Genes Involved in the Intracellular Survival of H. capsulatum Yeasts |
|
|
573 | (6) |
|
Immunology of Phagosomes Containing H. capsulatum Yeasts |
|
|
579 | (1) |
|
|
|
579 | (4) |
|
|
|
580 | (3) |
|
Leishmania: L. mexicana vs. donovani vs. major, Amastigotes vs. Promastigotes |
|
|
583 | (14) |
|
|
|
|
|
|
|
Leishmania and Leishmaniases |
|
|
583 | (1) |
|
Characterization of Intra-Host Cell Compartmentation of Leishmania and its Relationships to Virulence |
|
|
584 | (2) |
|
Leishmania Molecules Involved in Diverted Phagosome Maturation/Compartment Maintenance |
|
|
586 | (6) |
|
Immunology of Phagosomes Containing Leishmania |
|
|
592 | (1) |
|
|
|
593 | (4) |
|
|
|
593 | (4) |
|
|
|
597 | (16) |
|
|
|
|
|
|
|
|
|
597 | (2) |
|
|
|
599 | (1) |
|
Characterization of Intra-Host Compartmentation and its Relationship to Virulence |
|
|
600 | (7) |
|
From Parasite Cell Biology and Genomics to Drug Targets |
|
|
607 | (2) |
|
|
|
609 | (4) |
|
|
|
609 | (4) |
|
|
|
613 | (20) |
|
|
|
|
|
Introduction to Theileria and the Disease |
|
|
613 | (2) |
|
Characterization of the Intra-Host Cell Compartment ... Which Compartment? |
|
|
615 | (8) |
|
Genes Involved in Host-Parasite Interaction |
|
|
623 | (2) |
|
Immune Responses Directed Against the Schizont |
|
|
625 | (1) |
|
|
|
626 | (7) |
|
|
|
628 | (5) |
|
|
|
633 | (22) |
|
|
|
Introduction of Toxoplasma gondii and Toxoplasmosis |
|
|
633 | (2) |
|
Characterization of the Intracellular Compartment Occupied |
|
|
635 | (3) |
|
|
|
Parasite Factors Involved in Maturation and Maintenance of the Parasite-Containing Vacuole |
|
|
638 | (3) |
|
Immunology of the Intracellular Compartment Occupied |
|
|
641 | (5) |
|
|
|
|
|
646 | (9) |
|
|
|
647 | (8) |
|
|
|
655 | (14) |
|
|
|
Introduction: The Parasite and its Disease |
|
|
655 | (2) |
|
Intracellular Compartmentation of T. cruzi |
|
|
657 | (6) |
|
Maintenance of the Infected Cell |
|
|
663 | (1) |
|
Immunology of T. cruzi Infection |
|
|
664 | (2) |
|
|
|
666 | (3) |
|
|
|
667 | (2) |
|
Trichinella and the Nurse Cell |
|
|
669 | (20) |
|
|
|
|
|
Introduction to Trichinella and Trichinellosis |
|
|
669 | (2) |
|
Remodeling of the Host Cell Compartment by Trichinella |
|
|
671 | (8) |
|
Parasite Molecules Involved in the Remodeling and Maintenance of the Nurse Cell Complex |
|
|
679 | (5) |
|
The Immunology of the Nurse Cell |
|
|
684 | (2) |
|
|
|
686 | (3) |
|
|
|
686 | (3) |
| Index |
|
689 | |
Lisainfo e-raamatute kohta