Introduction to the Series |
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vii | |
Preface |
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ix | |
Notations |
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xi | |
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Background to Modern Statistical Genetics |
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1 | (42) |
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Introduction: Where is the Gene? |
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1 | (4) |
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Function of Genes in Reproduction |
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5 | (9) |
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Some Facts in Molecular Genetics |
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14 | (8) |
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Tools in Molecular Genetics |
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22 | (8) |
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30 | (13) |
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39 | (4) |
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Linkage Analysis with Qualitative Trait |
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43 | (54) |
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Basic Concepts in Pedigree Analysis |
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43 | (10) |
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Linkage Analysis for Large Pedigrees |
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53 | (12) |
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Incomplete Penetrance and Sibling Studies |
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65 | (17) |
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Designs in Linkage Analysis |
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82 | (15) |
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92 | (5) |
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Genetics of Quantitative Trait |
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97 | (60) |
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Quantitative Trait Locus (QTL) Based on Sibpairs |
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97 | (10) |
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Interval Mapping of Quantitative Trait Loci |
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107 | (19) |
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126 | (14) |
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Breeding Value Evaluation Models |
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140 | (17) |
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154 | (3) |
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157 | (38) |
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Small Area Gene Mapping by Linkage Disequilibrium |
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157 | (9) |
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Gene, Exon and Intron Identification |
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166 | (6) |
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Reconstruction of Evolutionary Path |
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172 | (10) |
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Forensic Evidence Using Genetic Markers |
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182 | (13) |
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192 | (3) |
Appendix A. Statistical Results Useful in Genetics |
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195 | (18) |
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A.1 Multivariate Analysis and Regression |
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195 | (4) |
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A.2 Likelihood Ratio Test and General Linear Models |
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199 | (5) |
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A.3 Multinomial Distribution |
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204 | (2) |
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A.4 Inference on Frequency Tables |
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206 | (2) |
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A.5 Discriminant Analysis and Neural Network |
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208 | (5) |
Appendix B. Selected Public Domain Computer Programs for Genetic Data Analysis |
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213 | (14) |
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B.1 A Teaching Linkage Analysis Program for Two Generation Families |
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213 | (4) |
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B.2 A Simulation Program to Compute ELOD and Var(LOD) for Two Generation Families |
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217 | (2) |
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B.3 Liped and Programs Described in Terwilliger and Ott's Handbook |
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219 | (1) |
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B.4 Simlink---Power Prediction for Given Pedigrees |
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220 | (1) |
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B.5 SIB--PAIR: A Nonparametric Linkage Software |
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221 | (1) |
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B.6 Mapmaker/SIBS, Mapmaker/QTL, Genehunter, GAS (Genetic Analysis System) |
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222 | (1) |
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B.7 A SAS Program to Compute Kinships Coefficients |
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223 | (1) |
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B.8 Using SAS-IML to Solve Handerson's Equation |
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224 | (1) |
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B.9 ETDT (Extended Transmission Disequilibrium Test) |
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225 | (1) |
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B.10 GeneBank and Genetic Data Sources |
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225 | (2) |
Answers or Hints to Exercises |
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227 | (6) |
Bibliography |
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233 | (12) |
Index |
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245 | |