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E-raamat: Life Extension: Lessons from Drosophila

  • Formaat: PDF+DRM
  • Sari: Healthy Ageing and Longevity 3
  • Ilmumisaeg: 09-Jun-2015
  • Kirjastus: Springer International Publishing AG
  • Keel: eng
  • ISBN-13: 9783319183268
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  • Formaat: PDF+DRM
  • Sari: Healthy Ageing and Longevity 3
  • Ilmumisaeg: 09-Jun-2015
  • Kirjastus: Springer International Publishing AG
  • Keel: eng
  • ISBN-13: 9783319183268

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?This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans.

Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine.

This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Part I Genetic Regulation of Longevity
1 Neuronal Genes and Developmental Neuronal Pathways in Drosophila Life Span Control
3(36)
Elena Pasyukova
Alexander Symonenko
Natalia Roshina
Mikhail Trostnikov
Ekaterina Veselkina
Olga Rybina
2 Gadd45 Proteins in Aging and Longevity of Mammals and Drosophila
39(28)
Alexey A. Moskalev
Ekaterina N. Proshkina
Mikhail V. Shaposhnikov
3 Superoxide Dismutase (SOD) Genes and Aging in Drosophila
67(16)
John Tower
4 Effect of Wolbachia Infection on Aging and Longevity-Associated Genes in Drosophila
83(24)
Oleksandr M. Maistrenko
Svitlana V. Serga
Alexander M. Vaiserman
Iryna A. Kozeretska
Part II Drosophila Models for Aging-Associated Diseases
5 Skeletal Muscle Homeostasis and Aging in Drosophila
107(20)
Melissa J. Puppa
Fabio Demontis
6 Drosophila Models of Cardiac Aging and Disease
127(24)
Alyson Sujkowski
Robert Wessells
7 Parallels Between Mammals and Flies in Inflammatory Bowel Disease
151(40)
Christofi Theodoulakis
Yiorgos Apidianakis
8 Protein Quality Control in Brain Aging: Lessons from Protein Misfolding Disorders in Drosophila
191(22)
Lorena de Mena
Pedro Fernandez-Funez
Diego E. Rincon-Limas
9 Drosophila Models in Therapeutic Drug Discovery Related to Aging
213(16)
Charles D. Nichols
Part III Life-Extending Treatments
10 Life-Extending Effect of Phytochemicals in Drosophila
229(16)
Lee Shin-Hae
Min Kyung-Jin
11 Life Extension in Drosophila by Histone Deacetylase Inhibitors
245(20)
Alexander M. Vaiserman
Elena G. Pasyukova
12 An Evolutionary Analysis of Healthspan Extension Using Diet: Have We Come to the End of the Ponce de Leon Trail?
265(20)
Grant A. Rutledge
Michael R. Rose
13 Atmosphere, Metabolism and Longevity
285(16)
Khatchik Muradian
14 Effects of Mild Stresses Applied in Adults on Aging and Longevity
301(20)
Eric Le Bourg
15 Strategies for Stage-Specific Extension of Longevity
321(28)
Robert Arking
Index 349