Reviewing the most current research in this rapidly expanding yet resource-limited field, Lipid-Mediated Signaling provides a much needed examination of a decade’s worth of research tying pathologic disorders such as cancer and autoimmunity to aberrant or deregulated signal transduction processes. It considers particular cells, tissues, and organ systems, and discusses recent efforts to identify the various signaling proteins that govern their behavior. Divided into five sections, the book covers fatty acid metabolism, eicosanoid formation, acyl-hydrolase activity, phospholipids and nuclear signaling, and gene expression.
As the highly anticipated update to Lipid Second Messengers (CRC Press, 1999), Lipid-Mediating Signaling is a current and comprehensive overview of research methods used in lipid-mediated signal transduction. Pioneering experts provide a much-needed distillation of a decade’s worth of advances in research techniques that are pertinent in understanding how lipid-mediated signal transduction ties to pathologic disorders.
Part I describes methods used to identify activities of and assay the expression of different enzymes involved in lipid-mediated signaling. Part II highlights the use of mass spectrometry to ascertain the lipid content in various systems. Part III contains two chapters devoted to techniques used to determine the role of lipids in the activation of gene transcription. Part IV rounds out the book’s solid coverage by focusing on methods used to assess fatty acid uptake and metabolism.
Lipid-Mediating Signaling is an unrivaled reference for this rapidly expanding, yet resource-limited field, and it is a valuable resource for for cell biologists, biochemists, and pharmacologists, as well as for researchers studying signaling transduction.
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