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E-raamat: Nanostructures and Nanoconstructions based on DNA

  • Formaat: EPUB+DRM
  • Ilmumisaeg: 04-Jun-2012
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781040192627
  • Formaat - EPUB+DRM
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 04-Jun-2012
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781040192627

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"Written for chemists, physicists, molecular biologists, and students in related fields, this reference covers information presently available on the specific properties of metallic nanoparticles, and compares their properties with those related to nanoobjects formed by biological molecules. It also discloses details of formation and physic-chemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. Timely in publication, the reference contains more DNA physics and molecular biologythan other published titles. Authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are of great interest in the development of various nanoscale systems and devices of practical importance"--



Evolutionally optimized biomolecules and their complexes present attractive objects in the production of functionalized nanoobjects. Indeed, nucleic acid-based molecules are primary candidates as building blocks for development of nanoscale systems and devices.

Written for chemists, physicists, molecular biologists, and students in related fields, Nanostructures and Nanoconstructions Based on DNA covers specific properties of metallic nanoparticles, and compares their properties with those related to nanoobjects formed by biological molecules. It also discloses details of formation and physicochemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. Furthermore, the book considers:

  • The peculiarities of two approaches to structural DNA nanotechnology, i.e. to creation of spatial nanoobjects formed by DNA molecules and their complexes: (i) the hybridization approach and (ii) the liquid-crystalline approach
  • The physicochemical properties of DNA nanostructures as well as "liquid" and "rigid" DNA-based nanoconstructions
  • The connection of liquid crystalline phase formation in DNA with possible nanotechnological applications

This timely reference covers more DNA physics and molecular biology than any other published title. The authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are an area of increasing significance in the development of various nanoscale systems and devices of practical importance.

Foreword ix
Editor's Preface xi
Authors' Preface xv
Introduction xvii
Chapter 1 Nanoparticles and Biological Molecules
1(40)
1.1 Metal Nanoparticles and Their Properties
1(11)
1.1.1 Properties of Atoms on the Surface of a Particle Determine the Appearance of a Number of New Properties
2(6)
1.1.2 Plasmon Resonance and the "Quantum Size Effect" Determine the Optical Properties of Nanoparticles
8(4)
1.2 Biological Molecules: A New Background for the Creation of Nanoobjects
12(9)
1.3 Organization of Research in Nanotechnology Area
21(3)
1.4 The Health Risk of Nanomaterials
24(12)
1.5 Summary
36(5)
References
36(5)
Chapter 2 Nanostructures Formed by Hybridization of Synthetic Single-Stranded DNA Molecules
41(50)
2.1 General Concept of the Fundamental Properties of DNA Used in Nanotechnology
41(10)
2.2 Hybridization Technique of Creating Nanostructures Based on Synthetic Single-Stranded DNA Molecules (Bottom-Up Approach to the Creation of DNA Nanostructures)
51(21)
2.3 Organic Linker Molecules as Rigid "Vertices" in the Tailored Spatial DNA Nanostructures Formed by Hybridization Technique
72(7)
2.4 Arrangement of Objects on the Surface of DNA Nanostructures
79(8)
2.5 Summary
87(4)
References
88(3)
Chapter 3 "Liquid" Nanoconstructions Based on Spatially Ordered Double-Stranded DNA Molecules
91(32)
3.1 Double-Stranded DNA Molecules as Building Blocks for Nanotechnology
91(3)
3.2 Phase Exclusion of Double-Stranded DNA Molecules from Polyethylene Glycol Solutions
94(3)
3.3 The Cholesteric Mode of Nucleic Acid Molecules Packing in Particles of Dispersions Results in an Appearance of Abnormal CD Spectra
97(11)
3.4 Accumulation of the "Guest" Molecules in the DNA Molecules Forming CLCD Particles
108(9)
3.5 Summary
117(6)
References
119(4)
Chapter 4 "Rigid" Nanoconstructions Based by Spatially Ordered Double-Stranded DNA Molecules Complexed with Various Compounds and Nanoparticles
123(64)
4.1 Backgrounds for Formation of Rigid DNA Nanoconstructions
123(2)
4.2 Rigid Nanoconstructions Formed as a Result of Formation of Nanobridges between Neighboring DNA Molecules Fixed in Quasinematic Layers
125(7)
4.3 The Magnetometric Evaluation of Cu2+ Ions in the Content of Nanobridges Formed between Spatially Fixed DNA Molecules
132(1)
4.4 Visualization of Rigid DNA Nanoconstructions Linked with Nanobridges and Manipulations with These Nanoconstructions
133(5)
4.5 Dependence of Optical Properties of DNA Nanoconstructions on Temperature
138(4)
4.6 Rigid Nanoconstruction Formed as a Result of Formation of Complexes of DNA Molecules Fixed in Quasinematic Layers with Rare-Earth Metal Cations
142(8)
4.7 Visualization of Rigid Particles of Cholesteric Liquid-Crystalline Dispersion of a [ DNA-Gd3+] Complex
150(8)
4.8 Au Nanoparticles Can Induce Formation of Rigid DNA Nanoconstruction
158(10)
4.9 An Additional Case: Formation of Semi-Rigid Liquid-Crystalline Particles
168(10)
4.10 Summary
178(9)
References
180(7)
Chapter 5 Viral Particles as "Rigid" Biological Nanoconstructions: Their Creation and Medical Application Prospects
187(22)
5.1 A "PEG-Like Situation" in Biological Systems and Peculiarities of Biological Nanoconstructions
188(2)
5.2 Methods for Obtaining Recombinant Adenovirus "Rigid" Nanostructures
190(2)
5.3 Recombinant Adenovirus Nanostructures with a Modified Genome
192(1)
5.4 Replication-Competent Recombinant Adenovirus Nanostructures
193(1)
5.5 Replication-Incompetent Recombinant Adenovirus Nanostructures
194(2)
5.6 Capsid-Modified Recombinant Adenovirus Nanostructures
196(1)
5.7 Physicochemical Modifications of Recombinant Adenovirus Particles
197(1)
5.8 Application of Recombinant Adenovirus Nanostructures in Medicine
198(6)
5.8.1 Use of RAVNs in Gene Therapy
198(2)
5.8.2 Use of RAVNs in Vaccination
200(2)
5.8.3 Constructing RAVNs for Noninvasive Diagnostics
202(2)
5.9 Summary
204(5)
References
204(5)
Chapter 6 Application of "Liquid" and "Rigid" DNA Nanoconstructions Immobilized in Polymeric Hydrogel as Sensing Units
209(14)
6.1 Issues of Stabilization of Particles of Liquid-Crystalline Dispersions
209(2)
6.2 Immobilization of DNA LCD Particles in a Hydrogel
211(7)
6.3 Formation and Immobilization of DNA Nanoconstruction in a Hydrogel
218(2)
6.4 Summary
220(3)
References
221(2)
Index 223
Chemists, physicists, molecular biologists, and other scientists and students of related fields.