| Foreword |
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ix | |
| Editor's Preface |
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xi | |
| Authors' Preface |
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xv | |
| Introduction |
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xvii | |
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Chapter 1 Nanoparticles and Biological Molecules |
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1 | (40) |
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1.1 Metal Nanoparticles and Their Properties |
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1 | (11) |
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1.1.1 Properties of Atoms on the Surface of a Particle Determine the Appearance of a Number of New Properties |
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2 | (6) |
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1.1.2 Plasmon Resonance and the "Quantum Size Effect" Determine the Optical Properties of Nanoparticles |
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8 | (4) |
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1.2 Biological Molecules: A New Background for the Creation of Nanoobjects |
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12 | (9) |
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1.3 Organization of Research in Nanotechnology Area |
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21 | (3) |
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1.4 The Health Risk of Nanomaterials |
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24 | (12) |
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36 | (5) |
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36 | (5) |
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Chapter 2 Nanostructures Formed by Hybridization of Synthetic Single-Stranded DNA Molecules |
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41 | (50) |
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2.1 General Concept of the Fundamental Properties of DNA Used in Nanotechnology |
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41 | (10) |
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2.2 Hybridization Technique of Creating Nanostructures Based on Synthetic Single-Stranded DNA Molecules (Bottom-Up Approach to the Creation of DNA Nanostructures) |
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51 | (21) |
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2.3 Organic Linker Molecules as Rigid "Vertices" in the Tailored Spatial DNA Nanostructures Formed by Hybridization Technique |
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72 | (7) |
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2.4 Arrangement of Objects on the Surface of DNA Nanostructures |
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79 | (8) |
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87 | (4) |
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88 | (3) |
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Chapter 3 "Liquid" Nanoconstructions Based on Spatially Ordered Double-Stranded DNA Molecules |
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91 | (32) |
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3.1 Double-Stranded DNA Molecules as Building Blocks for Nanotechnology |
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91 | (3) |
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3.2 Phase Exclusion of Double-Stranded DNA Molecules from Polyethylene Glycol Solutions |
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94 | (3) |
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3.3 The Cholesteric Mode of Nucleic Acid Molecules Packing in Particles of Dispersions Results in an Appearance of Abnormal CD Spectra |
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97 | (11) |
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3.4 Accumulation of the "Guest" Molecules in the DNA Molecules Forming CLCD Particles |
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108 | (9) |
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117 | (6) |
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119 | (4) |
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Chapter 4 "Rigid" Nanoconstructions Based by Spatially Ordered Double-Stranded DNA Molecules Complexed with Various Compounds and Nanoparticles |
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123 | (64) |
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4.1 Backgrounds for Formation of Rigid DNA Nanoconstructions |
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123 | (2) |
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4.2 Rigid Nanoconstructions Formed as a Result of Formation of Nanobridges between Neighboring DNA Molecules Fixed in Quasinematic Layers |
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125 | (7) |
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4.3 The Magnetometric Evaluation of Cu2+ Ions in the Content of Nanobridges Formed between Spatially Fixed DNA Molecules |
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132 | (1) |
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4.4 Visualization of Rigid DNA Nanoconstructions Linked with Nanobridges and Manipulations with These Nanoconstructions |
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133 | (5) |
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4.5 Dependence of Optical Properties of DNA Nanoconstructions on Temperature |
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138 | (4) |
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4.6 Rigid Nanoconstruction Formed as a Result of Formation of Complexes of DNA Molecules Fixed in Quasinematic Layers with Rare-Earth Metal Cations |
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142 | (8) |
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4.7 Visualization of Rigid Particles of Cholesteric Liquid-Crystalline Dispersion of a [ DNA-Gd3+] Complex |
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150 | (8) |
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4.8 Au Nanoparticles Can Induce Formation of Rigid DNA Nanoconstruction |
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158 | (10) |
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4.9 An Additional Case: Formation of Semi-Rigid Liquid-Crystalline Particles |
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168 | (10) |
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178 | (9) |
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180 | (7) |
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Chapter 5 Viral Particles as "Rigid" Biological Nanoconstructions: Their Creation and Medical Application Prospects |
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187 | (22) |
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5.1 A "PEG-Like Situation" in Biological Systems and Peculiarities of Biological Nanoconstructions |
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188 | (2) |
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5.2 Methods for Obtaining Recombinant Adenovirus "Rigid" Nanostructures |
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190 | (2) |
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5.3 Recombinant Adenovirus Nanostructures with a Modified Genome |
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192 | (1) |
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5.4 Replication-Competent Recombinant Adenovirus Nanostructures |
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193 | (1) |
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5.5 Replication-Incompetent Recombinant Adenovirus Nanostructures |
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194 | (2) |
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5.6 Capsid-Modified Recombinant Adenovirus Nanostructures |
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196 | (1) |
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5.7 Physicochemical Modifications of Recombinant Adenovirus Particles |
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197 | (1) |
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5.8 Application of Recombinant Adenovirus Nanostructures in Medicine |
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198 | (6) |
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5.8.1 Use of RAVNs in Gene Therapy |
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198 | (2) |
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5.8.2 Use of RAVNs in Vaccination |
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200 | (2) |
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5.8.3 Constructing RAVNs for Noninvasive Diagnostics |
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202 | (2) |
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204 | (5) |
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204 | (5) |
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Chapter 6 Application of "Liquid" and "Rigid" DNA Nanoconstructions Immobilized in Polymeric Hydrogel as Sensing Units |
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209 | (14) |
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6.1 Issues of Stabilization of Particles of Liquid-Crystalline Dispersions |
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209 | (2) |
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6.2 Immobilization of DNA LCD Particles in a Hydrogel |
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211 | (7) |
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6.3 Formation and Immobilization of DNA Nanoconstruction in a Hydrogel |
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218 | (2) |
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220 | (3) |
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221 | (2) |
| Index |
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223 | |