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xi | |
Preface |
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xiii | |
Acknowledgments |
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xv | |
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I OVERVIEW OF EXERCISE AND NEUROLOGICAL CHANGES |
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1 Effects of Physical Activity on the Cerebral Networks |
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What Is Cognitive Ageing? |
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3 | (1) |
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Physical Exercise and Health |
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4 | (1) |
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Cognitive Ageing and Cerebral Networks |
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5 | (2) |
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Physical Activity, Cognitive Reserve, and Neuroplasticity: Three Allies for Successful Ageing |
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7 | (1) |
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Molecular Basis of Exercise and the Ageing Brain |
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8 | (1) |
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8 | (1) |
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9 | (4) |
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2 Exercise and the Developing Brain in Children and Adolescents |
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Measuring Physical Activity Levels and Aerobic Fitness in Youth |
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13 | (1) |
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Brain Development as Measured by Magnetic Resonance Imaging (MRI) |
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13 | (1) |
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Aerobic Exercise and Brain Structure |
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14 | (2) |
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Aerobic Exercise and Brain Activity |
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16 | (1) |
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Aerobic Exercise and Cognition |
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17 | (1) |
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Remaining Questions and Future Directions |
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17 | (1) |
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18 | (1) |
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18 | (3) |
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3 Differential Expression of the Brain Proteome in Physical Training |
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21 | (1) |
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22 | (1) |
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22 | (1) |
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Two-Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) |
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23 | (3) |
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26 | (1) |
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26 | (1) |
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26 | (3) |
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4 Physical Exercise-Induced Changes in Brain Temperature |
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29 | (1) |
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Measuring Brain Temperature During Exercise |
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30 | (1) |
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Effects of Exercise on TBRAIN |
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30 | (7) |
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37 | (1) |
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37 | (4) |
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II DRUGS OF ABUSE WITH EXERCISE TO MODIFY NEUROLOGICAL STRUCTURE AND FUNCTION |
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5 Physical Activity as a Therapeutic Intervention for Addictive Disorders: Interactions With Methamphetamine |
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41 | (1) |
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Animal Models of Drug Reinforcement and Reward to Illicit Drugs |
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42 | (1) |
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Animal Models of Sustained Physical Activity |
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43 | (1) |
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Convergence Between Methamphetamine Self-Administration and Sustained Physical Activity in Animal Models |
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43 | (2) |
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Neural Mechanisms Underlying Reinforcing Effects of Methamphetamine and Wheel Running |
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45 | (1) |
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Neuroprotection by Wheel Running: Significant Interactions With Methamphetamine-Induced Neurotoxicity |
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45 | (2) |
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Exercise as a Therapeutic Intervention for Methamphetamine Addiction |
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47 | (1) |
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48 | (1) |
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48 | (5) |
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6 Pharmacological Intervention of Brain Neurotransmission Affects Exercise Capacity |
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53 | (1) |
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The Structure and Function of the Nervous System |
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53 | (1) |
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Physiological Properties of Monoamines |
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54 | (3) |
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57 | (2) |
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Drugs Manipulating Brain Monoamine and Exercise Performance |
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59 | (3) |
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62 | (1) |
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63 | (2) |
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7 The Endocannabinoid System and Chronic Disease: Opportunity for Innovative Therapies |
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65 | (1) |
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History of the Runner's High |
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65 | (1) |
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Effects of Endocannabinoid System Stimulation |
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66 | (2) |
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Possibilities of Therapeutic Uses of the Endocannabinoid System in Chronic Conditions |
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68 | (1) |
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Brain Derived Neurotropic Factor and Depression |
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68 | (1) |
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69 | (1) |
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69 | (1) |
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Musculoskeletal Disorders |
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70 | (1) |
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70 | (1) |
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Amyotrophic Lateral Sclerosis (ALS) |
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71 | (1) |
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71 | (1) |
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72 | (1) |
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72 | (5) |
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III FACTORS MODULATING EXERCISE IN AGING AND NEUROLOGICAL CONSEQUENCES |
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8 Changes in Cerebral Blood Flow During Steady-State Exercise |
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77 | (1) |
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CBF Estimated by TCD Method |
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78 | (1) |
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rCBF Measurement Using PET |
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79 | (1) |
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Increased rCBF During Exercise: Underlying Possible Mechanisms |
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80 | (2) |
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Increased rCBF During Exercise and Beneficial Effects of Brain |
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82 | (1) |
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83 | (1) |
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83 | (1) |
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Disclosure/Conflict of Interest |
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83 | (1) |
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83 | (2) |
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9 Biochemical Mechanisms Associated With Exercise-Induced Neuroprotection in Aging Brains and Related Neurological Diseases |
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85 | (1) |
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Exercise Effects: Neurotrophic Factors |
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86 | (1) |
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Exercise Effects: Epigenetics |
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86 | (1) |
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Exercise Effects: Apoptosis |
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87 | (1) |
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Exercise Effects: Oxidative Stress |
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88 | (1) |
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Exercise Effects: Neurogenesis |
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88 | (1) |
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Exercise Effects: Synaptogenesis |
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89 | (1) |
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Exercise Effects: Age-Related Neurodegenerative Diseases |
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90 | (1) |
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91 | (1) |
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91 | (4) |
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10 Role of Melatonin Supplementation During Strenuous Exercise |
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Melatonin: Sources, Biosynthesis, and Physiological Effects |
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95 | (1) |
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Exercise: Oxidative Stress and Induced Inflammatory Signaling |
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96 | (1) |
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Melatonin and Inflammatory Signaling |
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97 | (1) |
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Effects of Melatonin in Strenuous Exercise |
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98 | (2) |
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100 | (7) |
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IV EXERCISE AS THERAPY FOR NEUROLOGICAL DISEASES |
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11 Mechanisms of Functional Recovery With Exercise and Rehabilitation in Spinal Cord Injuries |
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107 | (1) |
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Mechanisms Underlying of Rehabilitation |
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108 | (4) |
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Refining Rehabilitation Programs |
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112 | (3) |
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115 | (1) |
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116 | (5) |
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12 Neural Structure, Connectivity, and Cognition Changes Associated to Physical Exercise |
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121 | (8) |
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129 | (4) |
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13 The Effect of Exercise on Motor Function and Neuroplasticity in Parkinson's Disease |
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133 | (1) |
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133 | (2) |
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Exercise Interventions in Parkinson's Disease Patients |
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135 | (1) |
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The Effects of Exercise on the Parkinsonian Brain---Animal Models |
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135 | (2) |
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The Effects of Exercise on the Parkinsonian Brain---Human Studies |
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137 | (1) |
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138 | (1) |
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138 | (3) |
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14 Physical Exercise and Its Effects on Alzheimer's Disease |
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141 | (1) |
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Alzheimer's Disease and Level of Physical Activity |
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141 | (1) |
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Alzheimer's Disease and Physical Activity Programs |
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142 | (1) |
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Alzheimer's Disease, Physical Exercise, and Cognitive Functions |
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142 | (3) |
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Alzheimer's Disease, Physical Exercise, and Neuropsychiatric Symptoms |
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145 | (1) |
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Alzheimer's Disease, Physical Exercise, and Functional Capacity |
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145 | (1) |
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Alzheimer's Disease, Physical Exercise, and Biomarkers |
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146 | (2) |
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148 | (1) |
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148 | (3) |
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15 Cortical Reorganization in Response to Exercise |
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151 | (1) |
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152 | (3) |
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Fatigue-related Brain Reorganization |
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155 | (1) |
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Brain Reorganization After Stroke |
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156 | (1) |
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157 | (1) |
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157 | (4) |
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16 Exercise Enhances Cognitive Capacity in the Aging Brain |
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161 | (1) |
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161 | (1) |
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Making the Connection---Moving the Body Builds the Brain |
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162 | (1) |
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Physical Exercise for Preventing Age-Related Cognitive Decline |
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162 | (3) |
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Molecular and Cellular Building Blocks for Brain Remodeling by Exercise |
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165 | (3) |
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168 | (1) |
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168 | (7) |
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V LIFESTYLE EXERCISE AFFECTING NEUROLOGICAL STRUCTURE AND FUNCTION IN OLDER ADULTS |
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17 Synergistic Effects of Combined Physical Activity and Brain Training on Neurological Functions |
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175 | (1) |
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Leisure Activities Improves Cognition and Reduces the Risk of Dementia and AD |
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176 | (1) |
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Combined Physical and Cognitive Training Interventions Show Stronger Cognitive Benefits |
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176 | (2) |
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Mechanisms Underlying the Synergistic Effects of Combined Physical and Mental Activities for Healthy Brain Aging |
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178 | (2) |
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180 | (1) |
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181 | (4) |
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18 Physical Activity: Effects of Exercise on Neurological Function |
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185 | (1) |
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Age-related Functional and Structural Changes in the Human Brain |
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185 | (3) |
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Theories of Neural Plasticity in Older Adults |
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188 | (2) |
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Exercise and Neurological Changes |
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190 | (3) |
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Exercise as Therapy for Neurological Diseases |
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193 | (2) |
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195 | (1) |
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195 | (4) |
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19 Update of Nutritional Antioxidants and Antinociceptives on Improving Exercise-Induced Muscle Soreness |
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199 | (1) |
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Mechanisms Responsible for the DOMS |
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199 | (2) |
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Endogenous Antioxidants and Exercise-Induced Muscle Soreness |
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201 | (1) |
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Nutritional Antioxidants and Exercise-Induced Muscle Soreness |
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201 | (1) |
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201 | (3) |
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Functional Foods With High Antioxidant Concentrations |
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204 | (1) |
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Antinociceptive Supplements and Exercise-Induced Muscle Soreness |
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205 | (1) |
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206 | (3) |
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20 Effects of Exercise-Altered Immune Functions on Neuroplasticity |
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209 | (1) |
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Effects of Exercise on Immune Function |
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209 | (2) |
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Role of Exercise in Enhancing Brain Capacity Through Neuroplasticity |
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211 | (1) |
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212 | (1) |
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Effects of Exercise-Altered Immune Function on Neuroplasticity |
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213 | (2) |
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215 | (4) |
Index |
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219 | |